DEVELOPMENT OF A TWO-DIMENSIONAL STRUCTURE BIMETAL ZIF FOR HIGH-PERFORMANCE NON-ENZYMATIC URIC ACID ELECTROCHEMICAL SENSORS

• Main Author: Abdurrahman Abrori, Syauqi
• Format: Dissertations
• Language: Indonesia
• Subjects: Teknik (Rekayasa, enjinering dan kegiatan berkaitan)
• Online Access: https://digilib.itb.ac.id/gdl/view/71182
• Institution: Institut Teknologi Bandung

Uric acid is the product of the catabolism of purine nucleotides, such as adenine and guanine, and is a common compound found in urine and blood. Under pathophysiological conditions, the normal level of uric acid in the blood is 200 – 420 ?M. Irregular uric acid levels beyond these levels can cause various health problems. Therefore, measuring uric acid levels precisely is very necessary. The highly developed technology in uric acid detection is the biosensor. The most widely used biosensors today are electrochemical biosensors. However, the detection of uric acid by electrochemical techniques is still common using enzymes that are very sensitive to environmental influences. As a porous material with a very large area, metal-organic frameworks (MOF) can be used to capture and localize enzymes or bioreceptors for specific biomolecular targets, making them very useful in biosensor technology. Unfortunately, in bulk MOF the conductivity is low, and the active sites are difficult to reach, so they must be modified with other metals or carbonized. To reduce this limitation, two-dimensional morphological modifications, and the use of two metal cores or bimetallic MOF can be carried out. This study reports the synthesis of Zeolitic Imidazolate Framework (ZIF), a MOF with imidazolate ligands, with a two-dimensional structure with a core of cobalt and zinc using coprecipitation method and water solvent. The use of cobalt and zinc produced ZIF-L with a 2D leaf-like morphology. The resulting ZIF bimetal did not show significant changes in crystal structure when compared to the monometal variations. The composition of Co:Zn with a ratio of 1:1 produces ZIF-L-CoZn material which has the best electrocatalytic properties among all the samples synthesized. This is indicated by the highest peak oxidation current and the lowest Rct value among all samples. ZIF-L-CoZn11 has a sensitivity to uric acid of 0.138 ?A ?M-1. It also has a linear range at 10 – 1000 ?M and a detection limit of 2.33 ?M. ZIF-L-CoZn11 is also selective for uric acid and has good reproducibility. .