LITERATURE STUDY AND PHARMACOKINETICS INTERACTION OF TRADITIONAL INDONESIAN HERBS FOR ANTIHYPERTENSIVE
The prevalence number of Indonesian citizen who got diagnosed with hypertension, aged above 18 years old according to the doctors is 8,36%. RISKESDAS reported that those who got diagnosed combine their medication using herbal treatment and antihypertensive drugs at the same time. The use of combinat...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/71331 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | The prevalence number of Indonesian citizen who got diagnosed with hypertension, aged above 18 years old according to the doctors is 8,36%. RISKESDAS reported that those who got diagnosed combine their medication using herbal treatment and antihypertensive drugs at the same time. The use of combination products may cause pharmacodynamic and pharmacokinetic effect inside the body.
This literature study apt to analyze the data interaction that occurs from scientific articles on PubMed using (antihypertensive drugs) AND (antihypertensive herbal or plant) interaction as the main keywords, which resulted in relevant 327 articles. To narrow this study to become more specific, those articles are eliminated using inclusion criteria, including: the study conducted in the last 10 years (2011-2021), articles discussed about herbs that is included in Indonesian Herbal Pharmacopeia, herbs are not included in the list of forbidden plants to use conducted by Indonesian National Food & Drug Agency (NFDA), herbs has the antihypertensive potential, and the article discussed about the interaction between herbs and antihypertensive drugs which metabolized through CYP450 enzyme system.
In conclusion, 6 herb species named after Punica granatum, Camelia sinensis, Annona muricata, Persea americana, Hibiscus sabdariffa, dan Zingiber officinale have the potential to be used as active ingredients in hypertension medication. The herbs are able to affect the pharmacokinetics profile of antihypertensive drugs. Further study is necessary to increase the safety and efficacy in the use of combination products for diagnosed patients.
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