#TITLE_ALTERNATIVE#

• Main Author: A. (S2-428804), Almahdi
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/7154
• Institution: Institut Teknologi Bandung

Abstrak: <br /> <br /> <br /> A study was conducted to determine the teratogenic potential of dried water extract of Kayu Kasai (Tristania Sumatrana Mi q.) in mice. The extract was given by gavage at dose levels of 0, 600, 1200, and 2400 mg kg-1 from day 6 through 15 of gestation. Half of the dams were killed the day prior to parturition to expose the foetuses. A significant decrease in number of foetuses was observed in two highdose treated groups. Two thirds of the foetuses eviscerated for skeletal staining with Alizarin red, and the other rest third of the foetuses were hardened with Bouins fixation solution. No malformation were found in the eviscerated group. The incidence of cleft palate was observed in all of the treated groups, but they were unsignificant to Chi-square test p:0.05. The other half of dams were allowed to labour spontaneously. The behaviour of the pups were observed during weaning, one, one and half month old, respectively. A, significant decrease in number of the pups was observed in two highdose treated groups. The result indicated that neither foetuses nor pups pose any anomalies statistically, so it noted that the extract failed to show any evidence of teratogenic potential. in mice.