IN TERPENETRATIN G POLYMER NETWORK ALGINATE BASED AS WOUND DRESSING MATERIAL
The utili=ation of biopolymers has been 1videly accepted in many areas due to its eco-friendly. Especially in medical care, biopolyt ners are receiving great attention and are considered as apotentialfo r wound healing. Wound dressing material is one of medical needslvhich is the demand continues to...
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Kimia Nurjanah, Ane IN TERPENETRATIN G POLYMER NETWORK ALGINATE BASED AS WOUND DRESSING MATERIAL |
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The utili=ation of biopolymers has been 1videly accepted in many areas due to its eco-friendly. Especially in medical care, biopolyt ners are receiving great attention and are considered as apotentialfo r wound healing. Wound dressing material is one of medical needslvhich is the demand continues to raise. One of the rnost l11idely used biop olymersfor lilOund dressing is alginate. To improve alginate lVOrks as a l.vound dressing material, various alginate modifications lvith nanoparticles or syntheticpolymers have been developed. Jnterpenetrating Polymer Net111ork (JPN) has been r11idely used as a modification meth.od of the alginate.
Alginate is a linear copolyn1er consisting of llvo monomeric units, /3-D-mannuronic
(M) and a-L-guluronic (G). Alginate is contained in all types of bro111n algae (Phaeop hJ1ta) lvhich is one of the rnain components of cell 1vall. Alginate has the criterion as lvound dressing material because its non-toxic, biokompatibel and biodegradable, high absorbency, easy to use or removable, protective against bacteria attack and keep moisture around the lVOund. Jn addition, some l.vound dressing materials use alginate as its rm.v material because it isknor11n toencourage the gro1vth of nelv cell tissues and reduce inflammation so as to accelerate wound healing.
Alginate has relatively 10111 antibacterial properties, so it needs to be modified, fo r example lVith nanoparticles orsynthetic polymers. For exampl e, ZnO nanoparticles (-inc oxide) are one of many nanoparticles that has potential to be applied in the biomedicalfield because they have good antibacterialprop erties. Jn addition, ZnO has several ad·vantages including a stable chen1ical structure, non-toxic, and can be used as an additive into various tnaterials, and the price is relatively cheap. Alginate already has a netl,vork of cross/ inks and the use of synthetic polymers lvhich also have cross/inking net1.vorks is expected to improve mechanical resistance properties. SJ 1nthetic polymers have been l11idely used as 1vound dressing materials modified lVith biopolymers to improve the prop erties of the ,.11oi1nd dressing material. Some of the syntheticpolymers used in l11ound dressing materials are poly(vinyl alcohol) (PVA), poly (ethylene glycol) (PEG) and poly (ethylene glycol) methacrylate (PEGMA). As an exatnple the use of PEGMA is capable of making modifications of ZnO nanoparticles more compatible 111ith a biopolymer.
One of method that has been used for the manuf acture of 1vound dressing material is interpenetration Polymer Net111ork (JPN). JPN is a combination of t1110 polymers in neru1ork fo r1n, one of 1Vhich is the result of synthesis and or cross-linked 111ith each other. The ad11antage of JPN is its simple mixing technique, but it canp roduce a strong polymer material because two or more netlvorks 1vill be entangled in such a way that it can not be separated but not bonded to each other by chemical bonds. Through these advantages, JPN can fac ilitate alginate as a wound dressing material in imp roving its mechanicaJ and antibacterial resistance properties.
Jn this research have been modified alginate biop olytner 1-V ith ZnO nanop articles and synthetic polymer as one of the candidate of 1vound dressing material. Alginate can go rhrough S1velling and its crystallinity is 10111 so that it affects its rnechanical properties. Interpenetration of ZnO nanoparticles into the alginate matrix is able to limit the volume of alginate polymer chains 111ith ZnO surfac es asfi llers so as to improve the mechanical proper ties and their antibacterial proper tie. Addition of synthetic polymers that can cross/ink 111ith alginate can strengthen the bonding net111ork of JPN materials. This is the reason of utili=ation of JPN to obtain the func tional 1naterial of alginate as one of the expected 1vound dressing material.
Alginate-Zn O-PEGDMA (AZP) material synthesis 111as carried out directly and gradually. The pr oduct pr oduced in direct synthesis is AZP in theform of a gel (gAZP) and in the gradual synthesis of AZP niaterial in thefo rm of a membrane (mAZP). The variation of AZP material concentration 1vas made into 3 1vith the alginate comp osition made the same, while the ZnO and PEGDMA compositions 111ere made different 111ith a ratio of 1:3:5. AZP material characteri=ation 111as carried out using FTJR, SEM-EDS, HRTEM and studied its mechanical and antibacterial properties. Testing lVith FTJR confirmed that the fan ctional groups ZnO and PEGDMA appeared in the FTIR spectra of gAZP and mAZP. Morphological studies of gAZP and mAZP materials described the distribution of ZnO and PEGDMA both on the surf ace and in the alginate molecule 1vhich 1vas strengthened by confirmation v.1ith HRTEM. The study of the mechanical propert ies of the mAZP material l11as able to increase the tensile strength and elasticity by
20.70 MPa and 1753.68 MPa, respectively, compar ed to the mAlg as reference material. The study of antibacterial properties lllas confirmed by testing the inhibition of gAZP and mAZP materials. The percentage of inhibition of gAZP material against S. aureus and E. coli increased by 58.62% and 55.17% respectively compar ed to the gAlg compar ator material. In addition, thepercentage of inhibition of mAZP material against S. aureus and E. coli increased by 68.97% and 51.72% respectively compar ed to mAlg as reference rnaterial
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IN TERPENETRATIN G POLYMER NETWORK ALGINATE BASED AS WOUND DRESSING MATERIAL |
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IN TERPENETRATIN G POLYMER NETWORK ALGINATE BASED AS WOUND DRESSING MATERIAL |
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IN TERPENETRATIN G POLYMER NETWORK ALGINATE BASED AS WOUND DRESSING MATERIAL |
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IN TERPENETRATIN G POLYMER NETWORK ALGINATE BASED AS WOUND DRESSING MATERIAL |
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IN TERPENETRATIN G POLYMER NETWORK ALGINATE BASED AS WOUND DRESSING MATERIAL |
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in terpenetratin g polymer network alginate based as wound dressing material |
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id-itb.:715522023-02-14T13:51:23ZIN TERPENETRATIN G POLYMER NETWORK ALGINATE BASED AS WOUND DRESSING MATERIAL Nurjanah, Ane Kimia Indonesia Dissertations ivound dressing material, Interpenetration Polymer Netl vork (JPN), alginate, nanoparticle ZnO, polymer synthetic. INSTITUT TEKNOLOGI BANDUNG https://digilib.itb.ac.id/gdl/view/71552 The utili=ation of biopolymers has been 1videly accepted in many areas due to its eco-friendly. Especially in medical care, biopolyt ners are receiving great attention and are considered as apotentialfo r wound healing. Wound dressing material is one of medical needslvhich is the demand continues to raise. One of the rnost l11idely used biop olymersfor lilOund dressing is alginate. To improve alginate lVOrks as a l.vound dressing material, various alginate modifications lvith nanoparticles or syntheticpolymers have been developed. Jnterpenetrating Polymer Net111ork (JPN) has been r11idely used as a modification meth.od of the alginate. Alginate is a linear copolyn1er consisting of llvo monomeric units, /3-D-mannuronic (M) and a-L-guluronic (G). Alginate is contained in all types of bro111n algae (Phaeop hJ1ta) lvhich is one of the rnain components of cell 1vall. Alginate has the criterion as lvound dressing material because its non-toxic, biokompatibel and biodegradable, high absorbency, easy to use or removable, protective against bacteria attack and keep moisture around the lVOund. Jn addition, some l.vound dressing materials use alginate as its rm.v material because it isknor11n toencourage the gro1vth of nelv cell tissues and reduce inflammation so as to accelerate wound healing. Alginate has relatively 10111 antibacterial properties, so it needs to be modified, fo r example lVith nanoparticles orsynthetic polymers. For exampl e, ZnO nanoparticles (-inc oxide) are one of many nanoparticles that has potential to be applied in the biomedicalfield because they have good antibacterialprop erties. Jn addition, ZnO has several ad·vantages including a stable chen1ical structure, non-toxic, and can be used as an additive into various tnaterials, and the price is relatively cheap. Alginate already has a netl,vork of cross/ inks and the use of synthetic polymers lvhich also have cross/inking net1.vorks is expected to improve mechanical resistance properties. SJ 1nthetic polymers have been l11idely used as 1vound dressing materials modified lVith biopolymers to improve the prop erties of the ,.11oi1nd dressing material. Some of the syntheticpolymers used in l11ound dressing materials are poly(vinyl alcohol) (PVA), poly (ethylene glycol) (PEG) and poly (ethylene glycol) methacrylate (PEGMA). As an exatnple the use of PEGMA is capable of making modifications of ZnO nanoparticles more compatible 111ith a biopolymer. One of method that has been used for the manuf acture of 1vound dressing material is interpenetration Polymer Net111ork (JPN). JPN is a combination of t1110 polymers in neru1ork fo r1n, one of 1Vhich is the result of synthesis and or cross-linked 111ith each other. The ad11antage of JPN is its simple mixing technique, but it canp roduce a strong polymer material because two or more netlvorks 1vill be entangled in such a way that it can not be separated but not bonded to each other by chemical bonds. Through these advantages, JPN can fac ilitate alginate as a wound dressing material in imp roving its mechanicaJ and antibacterial resistance properties. Jn this research have been modified alginate biop olytner 1-V ith ZnO nanop articles and synthetic polymer as one of the candidate of 1vound dressing material. Alginate can go rhrough S1velling and its crystallinity is 10111 so that it affects its rnechanical properties. Interpenetration of ZnO nanoparticles into the alginate matrix is able to limit the volume of alginate polymer chains 111ith ZnO surfac es asfi llers so as to improve the mechanical proper ties and their antibacterial proper tie. Addition of synthetic polymers that can cross/ink 111ith alginate can strengthen the bonding net111ork of JPN materials. This is the reason of utili=ation of JPN to obtain the func tional 1naterial of alginate as one of the expected 1vound dressing material. Alginate-Zn O-PEGDMA (AZP) material synthesis 111as carried out directly and gradually. The pr oduct pr oduced in direct synthesis is AZP in theform of a gel (gAZP) and in the gradual synthesis of AZP niaterial in thefo rm of a membrane (mAZP). The variation of AZP material concentration 1vas made into 3 1vith the alginate comp osition made the same, while the ZnO and PEGDMA compositions 111ere made different 111ith a ratio of 1:3:5. AZP material characteri=ation 111as carried out using FTJR, SEM-EDS, HRTEM and studied its mechanical and antibacterial properties. Testing lVith FTJR confirmed that the fan ctional groups ZnO and PEGDMA appeared in the FTIR spectra of gAZP and mAZP. Morphological studies of gAZP and mAZP materials described the distribution of ZnO and PEGDMA both on the surf ace and in the alginate molecule 1vhich 1vas strengthened by confirmation v.1ith HRTEM. The study of the mechanical propert ies of the mAZP material l11as able to increase the tensile strength and elasticity by 20.70 MPa and 1753.68 MPa, respectively, compar ed to the mAlg as reference material. The study of antibacterial properties lllas confirmed by testing the inhibition of gAZP and mAZP materials. The percentage of inhibition of gAZP material against S. aureus and E. coli increased by 58.62% and 55.17% respectively compar ed to the gAlg compar ator material. In addition, thepercentage of inhibition of mAZP material against S. aureus and E. coli increased by 68.97% and 51.72% respectively compar ed to mAlg as reference rnaterial text |