SENYAWA FLAVONOID DARI KULIT BATANG INTSIA BIJUGA KUNTZE PAPUA (FABACEAE)
Intsia bijuga Kuntze (Fabaceae) or locally known as Kayubesi is a plant that produced high quality of woods and usually used for construction materials, furnitures, and music devices. In Papua, the stem bark of I. bijuga is used as traditional medicine to cure diarrehea and rheumatism. As consequ...
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| Format: | Final Project |
| Language: | Indonesia |
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| Online Access: | https://digilib.itb.ac.id/gdl/view/71702 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Intsia bijuga Kuntze (Fabaceae) or locally known as Kayubesi is a plant that
produced high quality of woods and usually used for construction materials,
furnitures, and music devices. In Papua, the stem bark of I. bijuga is used as
traditional medicine to cure diarrehea and rheumatism. As consequences of this
excessive exploitations, the species become threatened while a lot of knowledge
need to be explored especially for chemical studies. This plant has been reported to
contain flavonoids, stilbens, and terpenoids. In this investigations, three flavonoids
that have biogenetic relathionship have been isolated from the stem bark of I. bijuga,
namely aromadendrin, luteolin, and apigenin. The structure of these compounds
were determined based on spectroscopic data including UV-Vis, Infrared, and 1HNMR.
The cytotoxic activity of these compounds have been tested against the
murine leukemia P-388 cell and IC50 of these compounds are 57 ?g/mL; 0,27 ?g/mL
and 3,6 ?g/mL, respectively. Planarity of C ring and orto dihydroxy group of B ring effected
the increase of cytotoxicity. |
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