POROUS HYDROXYAPATITE MATERIAL ENGINEERING USING SUGARCANE BAGASSE AS PORE FORMER

• Main Author: Susanto, Reno
• Format: Theses
• Language: Indonesia
• Subjects: Teknik kimia
• Online Access: https://digilib.itb.ac.id/gdl/view/71818
• Institution: Institut Teknologi Bandung

The high number of accidents in Indonesia, both mild and severe, can result in bone damage, causing a high need for bone implants. One of the materials that can be used in bone implants is a synthetic biomaterial, namely hydroxyapatite. Hydroxyapatite (HA) is a mineral compound of the apatite group which has the chemical formula Ca10(PO4)6(OH)2. HA is the main inorganic component of hard biological tissues such as teeth and bone and has properties of osteoconductivity, chemical and biological affinity and biocompatibility very similar to bone tissue. The aims and objectives of this study were to make porous hydroxyapatite-based bone implants by utilizing bagasse as a pore former according to bone implant standards, to determine the effect of bagasse composition, stirring time and sintering temperature on the characteristics of the resulting HA scaffold. HA scaffold can be made using the sacrificial method using porogen bagasse as a pore former with the stages of material preparation, stirring, drying, burning and sintering. Full factorial experimental design of 23 was used in this study with the variable composition of bagasse, stirring time and sintering temperature used. The resulting HA scaffold has shrinkage in the range of 40-65%, density of 0.571-0.7 gr/cm3, porosity of 77.895-83.85%, pore size of 5-155 ?m and compressive strength of 1.28-5.24 MPa. The HA scaffold showed good biocompatibility as indicated by the presence of a layer of apatite on the surface of the HA scaffold. Toxicity prediction and molecular docking showed that the HA scaffold is not toxic and has the ability to bind to bone tissue. The characteristics of the HA scaffold obtained met the criteria as a bone implant.