UJI REAKTIVITAS AKRILAMIDA, BENZOPIREN, DCP, DAN 3-MCPD, TERHADAP ADENIN DAN GUANIN MENGGUNAKAN METODE KOMPUTASI.
Molecular study of DNA-carcynogen interaction can be carried out using different methods. Computational method is an alternative method to experimental methods which can be carried out in silico by applying computer progam. This paper describe the reactivity study of acrylamide, benzo[a]pyrene, D...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/72744 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Molecular study of DNA-carcynogen interaction can be carried out using different
methods. Computational method is an alternative method to experimental methods which
can be carried out in silico by applying computer progam. This paper describe the
reactivity study of acrylamide, benzo[a]pyrene, DCP and 3-MCPD, as food contaminants
having carcinogenic potency, against adenine and guanine using computational method.
The carcinogenic potencies of these contaminants can be predicted from their physicochemicals
parameters which can be calculated by computational method. Identification and
characterization of acrylamide, benzo[a]piren, DCP and 3-MCPD carcinogenicity’s based
on calculation’s results of physico-chemical parameters using semi-empirical and
molecular mechanic calculations. Both are calculation methods from hyperchem’s
software. Acrylamide has the lowest result of log P, molecular weight, and ionization
energy among other contaminants. 3-MCPD has the lowest steric hindrance among other
contaminants. Acrylamide has the strongest bonding with adenine and guanine among
other contaminants. Based on these result, acrylamide was predicted to be a contaminant
with the highest carcinogenic potency. The result of carcinogenic potencies with
descending reactivity : acrylamide, MCPD, benzo(a)pyrene, DCP. |
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