EFEK HIPNOTIK SEDATIF DAUN KANGKUNG AIR (IPOMOEA AQUATICA) DALAM BENTUK KOMBINASI DENGAN BUNGA LAVENDER (LAVANDULA ANGUSTIFOLIA) DAN DAUN MINT (MENTHA X PIPERITA) TERHADAP MENCIT JANTAN GALUR Â SWISS-WEBSTER

• Main Author: Adji Pratama, Bimo
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/73488
• Institution: Institut Teknologi Bandung

Sleep is one of the important physiological needs to maintain body balance and prevent disturbances in other parts of the body. Changes in sleep habits that can affect sleep quality are called sleep disorders. One common type of sleep disorder is insomnia, which can be addressed through pharmacological and non-pharmacological therapies. Some people believe that water spinach plants can induce drowsiness. Therefore, this study was conducted to examine the hypnotic and sedative effects of boiled water spinach leaves, lavender flowers, mint leaves, and their combination on mice. The hypnotic effects were assessed by measuring sleep latency, duration, efficiency, and dorsal temperature. The results of the hypnotic effects test showed that all experimental groups exhibited comparable hypnotic effects. The mint group showed the shortest sleep latency (138.2 ± 26.8 seconds), while the water spinach group showed the longest sleep duration (3122 ± 527 seconds) and the highest sleep efficiency (95.56 ± 1.06%). Additionally, the dorsal temperature observations indicated that the water spinach group produced the greatest temperature reduction at the beginning of the observation period and yielded significantly different results compared to the control. In the sedative effects test, the lavender group showed the best results compared to the other experimental groups. Based on the behavioral tests, the lavender group exhibited the lowest mean values in terms of alertness, touch response, and ptosis. The sedation rating scale results showed no significant differences between the experimental and control groups. In this study, the combination group did not provide better hypnotic-sedative effects than the individual experimental groups. Therefore, further research with variations in combination dosages is needed. Based on the observations, it can be concluded that the lavender group showed the best sedative effect, and all experimental groups exhibited comparable hypnotic effects.