ANTIHYPERTENSIVE ACTIVITY TEST OF ASHITABA HERB ETHANOL EXTRACT (ANGELICA KEISKEI) IN DEXAMETHASONE-INDUCED MALE WISTAR RATS

• Main Author: Eza Tiara, Nadia
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/73959
• Institution: Institut Teknologi Bandung

Hypertension or high blood pressure is a cardiovascular disease with one of the highest prevalences in the world. The usage of conventional medicines by patients with hypertension may cause various side effects that can lead to non-compliance with therapy, thus preventing the achievement of target therapy. Using natural materials as an alternative to hypertension therapy is expected to minimalize the occurrence of side effects. Japanese celery (lit. translated from the local name in Bahasa Indonesia) or ashitaba (Angelica keiskei) has been used by the people as a traditional medicine to lower blood pressure. Based on previous research, the leaf part of ashitaba was proven to have an antihypertensive effect in vitro. This research was done to determine the effects of the ashitaba herb extract on systolic blood pressure (SBP) & diastolic (DBP) when given to dexamethasone-induced hypertensive male Wistar rats through a non-invasive method of blood pressure measurement. The blood pressure is measured before induction, after induction, & during therapy (day 1, day 3, day 5, & day 7) using CODA® blood pressure system. The test animals are induced by injecting 0.5 mg/kg BW subcutaneously of dexamethasone injection. Captopril 4.5 mg/kg BW is used as the standard group. An increase in SBP & DBP happened significantly (p<0.05) in every induced animal group. After therapy for seven days, ashitaba herb extract in doses of 225 & 450 mg/kg BW can decrease SBP & DBP significantly (p<0.05). The average decrease of SBP in ashitaba herb group 225 & 450 mg/kg BW after day 7 of therapy are 30.0 & 29.6 mmHg, respectively, while the decrease of DBP is 24.6 & 23.35 mmHg, respectively. Ashitaba herb extract in 225 & 250 mg/kg doses shows antihypertensive effects on dexamethasone-induced hypertensive Wistar rats.