FLOW ANALYSIS OF CELLULAR PARALLEL FLOW CHAMBER SYSTEM BY COMPUTATIONAL FLUID DYNAMICS METHOD

• Main Author: Yacub, Olivia
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/74557
• Institution: Institut Teknologi Bandung

<p align="justify">Based on data from World Health Organization (WHO) in 2019, cardiovascular disease is the cause of death of 32% of the world's population. One of the causes of cardiovascular disease is stenosis (narrowing) of the blood vessels. The procedure to open the narrowed blood vessels is stent deployment. However, the presence of the stent in the blood vessel can cause changes in the mechanical environment of the blood vessel wall, including flow velocity patterns and wall shear stress (WSS) contours. In vitro experiments can be conducted using a cellular parallel flow chamber system, which is designed to have flow conditions similar to those in blood vessels. In these experiments, the behavior of endothelial cells is observed after being exposed to flow for 24 hours. It is known that changes in WSS values affect the proliferation and migration of endothelial cells. However, the WSS value cannot be measured by in vitro experiments. Therefore, computational simulations are needed to predict the WSS value. This prediction is to determine whether the WSS condition remains normal in the post-stent deployment vessel. In this Final Project research, a computer aided design (CAD) geometry model of the cellular parallel flow chamber system used in the in vitro experiments will be created to model the flow conditions without and after stent deployment in blood vessels. Then, a computational fluid dynamic (CFD) study was conducted to analyze the prediction of flow velocity patterns and WSS values and their effects on endothelial cells using a computational method based on the finite volume method (FVM). From this study, it was concluded that the presence of a stent in a blood vessel will definitely affect the flow velocity pattern as well as the WSS contour. The greater the distance between parallel wires, the further away from normal blood vessel conditions. From 1-3 mm gap variation, 1 mm gap is the optimal distance between parallel wires so that the change in WSS is minimal.