THE EFFECT OF BLOOD VOLUME FRACTION AND PLASMA-ERYTHROCYTE RATIO ON FDG PHARMACOKINETIC MODEL STUDIES IN INFANTS

• Main Author: Feodora Christine M, Edytha
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/77190
• Institution: Institut Teknologi Bandung

One of the radiopharmaceutical substances used in nuclear medicine is Fluorodeoxyglucose (FDG). Cancer screening is one of the important things in the world of health, one of the tools used is PET. PET can be used in infants and there are already scientific journals discussing this such as scientific journals written by Niven and Khamwan. In both journals discuss the radioactivity that occurs in premature infants in the imaging process using PET and FDG radiopharmaceuticals, but the two studies have different activity calculation values. So this research will discuss the same thing as the two studies but considering the factor of blood volume fraction and plasmaerythrocyte ratio. The first thing to do in this research is to determine the model for imaging premature babies using FDG on PET. The modeling in this study was adapted from Khamwan’s journal which resulted 11 compartments. This modeling describes the transfer of FDG substances in each organ so the biological decay equation can be determined in the form of ordinary differential equations. The solution of the ordinary differential equation will be solved by the Euler method. After obtaining the solution of the ordinary differential equation, the sample equation will be calculated. The sample equation consists of 5 core organs formed from 11 compartments modeling. The sample equation is formed from the solution of the Euler equation, physical decay, blood volume fraction, and plasma-erythrocyte ratio. The addition factor of blood volume fraction and plasma-erythrocyte ratio will be a modified factor in the sample equation by adjusting the condition of the object of research, which is premature babies. Based on the modifications made, 3 sample equation models will be produced, namely models A, B, and C. Model A is a sample equation in accordance with Khamwan’s journal. Model B is a sample equation that adds the plasma-erythrocyte ratio factor. Model C is a sample equation that uses the fraction of blood volume in premature babies. Based on the calculation results, model C is closest to the results found in Niven’s paper with the support of factors suitable for premature infants. However, there are still many differences between the results of model C and the results in Niven’s paper, so further research is needed on other factors that affect FDG radioactivity in premature infants.