IDENTIFICATION SOLID INTERACTION OF PIOGLITAZONE HCL AND METFORMIN HCL AND ITS INFLUENCE ON THE DISSOLUTION OF PIOGLITAZONE HCL

• Main Author: Zulkarnain Mahmud Bade, Iskandar
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/78608
• Institution: Institut Teknologi Bandung

Purpose To identify the physical interaction between PGZ-MFN and its influence on the solubility and dissolution PGZ. Methods Solid state interaction was observed by cold. contact method and phase diagram formation. The solid state grinding (SSG), solvent drop grinding (SDG) and solvent evaporation (SE) was conducted on binary mixtures. The identification results in a binary system was characterized by differential thermal analysis (DTA), polarization microscopy, scanning electron microscope (SEM) and powder X-ray diffraction (PXRD). Furthermore, the solubility and dissolution testing of PGZ performed on the physical interaction results. Results The observation under the polarizing microscope showed that the new crystal habit was not found. Increase temperature showed that the mixture has melting point lower than MFN and PGZ. Those phenomenon was then confirmed with phase diagram arranged by thermogram of PGZ-MFN. That was identified mixture binary equimolar as eutectic mixture with eutectic temperature 1 87 0 C. Meanwhile, PXRD data at equimolar mixture did not showed the new interference peak. The DTA and powder X-ray diffraction data of the equimolar solid compounds obtained from several tehnique showed similar result. The thermogram of all treated sampels had similar endothermic curve (1851 860C), and identical interference peaks of PGZ-MFN of26 8.6; 12.2; 12.8; 17.2; 18.6; 22.7; 23.20 . On the eutectic mixture. solubility and dissolution ofPGZ lower than PGZ alone. The solubility of PGZ influenced by pH. The higher of the pH due to the presence of more of MFN the lower solubility of PGZ. Conclusion Based on the results of morphological analysis; {he data PXRD and thermal properties, PGZ-MFN equimolar mixture showed the formation of a eutectic mixture without increment the solubility and dissolution PGZ. The more concentration of MFN in binary mixture the lower PGZ solubility.