ANALGESIC ACTIVITUY OF WATER EXTRACT, 70 % ETHANOL EXTRACT AND 96% ETHANOL EXTRACT OF BINAHONG ANIEDERA CORDIFOLIA} (TEN.) V. STEENIS)LEAVES ON SWISS WEBSTER MICE AND WISTAR RAT

• Main Author: Mbunga, Dominus
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/78861
• Institution: Institut Teknologi Bandung

Pain is symptom of disease with high prevalence in the world. One model for therapy that may have benefit in reducing pain is using binahong (Anredera cordifolia (Ten.) v. Steenis) leaves, which was traditionally used by community. There was no study that proved analgesic activity of binahong leaves, but many researches were performed scientifically for many diseases. This research aimed to prove analgesic activity of binahong leaves scientifically and compare analgesic activity of water extract, 70 % ethanol extract, 96 % ethanol extract of binahong leaves. Extraction was conducted by reflux method. Analgesic peripheral activity of water extract, 70 % ethanol extract and 96 % ethanol extract ofbinahong leaves with doses of 50 mg/kg bw, 100 mg/kg bw and 200 mg/kg bw were performed which induced by acetic acid 0.6 % (Siegmund method) and analgetic central activity which induced by heating (tail immersion method). All of doses of water extract, 70% ethanol extract and 96 % ethanol extract of binahong leaves had analgesic activity which was significantly different with control (p<0,05). In Siegmund method, water extract with doses of 100 mg/kg bw and 200 mg/kg bw had the highest analgesic activity which were not significantly different with aspirin, while in tail immersion method all of binahong leaves extracts were not significantly differerent among extracts, but their analgesic activity were lower thali aspirin (p<0.05). Water extract, 70 % ethanol extract, 96 % ethanol extract of bieahong leaves had analgesic activity by central and peripherally.