EFFECT OF CURCUMIN ON ALCOHOL WITHDRAWAL SYNDROME OR ALCOHOL DEPENDENCE MICE

• Main Author: Sinata, Novia
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/78898
• Institution: Institut Teknologi Bandung

Alcohol dependence has become a major cause of health and socio-economic related problems. According to WHO, 3.3 millions deaths occurred due to adverse effects of alcohol consumption in 2012. Alcohol dependence is usually accompanied by tolerance and symptoms of alcohol withdrawal that occurs when reducing or stopping alcohol consumption. Previous study have shown that administration of prostaglandin synthesis inhibitor reduced withdrawal signs. Curcumin has been known as an agent that prostaglandin inhibits synthesis. The aim of this study was to investigate the effects of curcumin in alcohol withdrawal syndrome. Mice were made alcohol dependent with administration of 15% alcoholic drink in 2% sucrose for 20 days. The effect of curcumin was evaluated by administration of 1 mg/kg bw, 3.2 mg/kg bw and 10 mg/kg bw curcumin once a day orally. Daily ethanol intake was measured. On the 21 st day, three hours after alcohol cessation, mice were induced with 10 mg/kg bw diclofenac. Twenty five minutes after, behavior symptoms of withdrawal were recorded followed by body weight measurements. In addition forced swim test (FST) was conducted to observe depressive symptom. Measurement of brain acetylcholine esterase (AChE) activity were also carried out. Result showed that there was no significant difference in the volume of drink between test group and positive control while volume of drink of test group was significantly decreased compared to normal group.Withdrawal symptoms of facial preening, fore paw licking, and groommg in mice treated with curcumin 3.2 mg/kg bw and 10 mg/kg bw were significantly decreased compared to positive control. Body weight in test groups significantly decreased compared to normal group. Immobility observed during FST was not significantly different among groups. Curcumin significantly decreased acetylcholine esterase (AChE) activity compared to positive control. Results of this study indicate that curcumin might help to reduce withdrawal symptoms of alcohol.