THE USE OF DRUG FOR SODIUM AND POTASSIUM DISORDERS TREATMENT IN PATIENTS WITH END-STAGE RENAL DISEASE

• Main Author: Friscia Yusri, Yunisa
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/78905
• Institution: Institut Teknologi Bandung

End-stage renal disease can disturb the electrolyte balance regulation, such as Na and K. Disturbances in the electrolyte balance ofNa and K in the body can becaused by decrease in renal function and the effect of antihypertensive drugs, including RAAS (Renin Angiotensin Aldosterone System) inhibitors such as ACEI (Angiotensin-Converting Enzyme Inhibitor) dan ARB (Angiotensin Receptor Blocker). Disturbances in the electrolyte balance of the body affects the cardiovascular system which can cause arrhythmia, brain edema, cardiac arrest and death. This study aims to determine the use of drugs to treat the electrolyte Na and K disorders and the effect* of ACEI and ARB chugs to the electrolytes Na and K disorders in the predialysis patients with end-stage renal disease. This research is a cross-sectional descriptive study on predialysis patients with end-stage renal disease in Muhammadiyah Hospital Bandung. This study obtains 22 patients that fit inclusion criteria. Those patients are the one who had the results of measurements of Na and K levels in predialysis. Based on the results, there were 59,09% had hyponatremia, 40,91% with normal conditions, and no patients experienced hypernatremia. And also, there were 45,45% experience hyperkalemia, 50,00% with normal conditions, and 4,55% had hypokalemia. Based on the severity of hyponatremia and hyperkalemia, 61,54% had mild hyponatremia, 23,08% had moderate hyponatremia, 15,38% had severe hyponatremia, 30,00% experienced mild hyperkalemia, 30,00% had moderate hyperkalemia, and 40,00% had severe hyperkalemia. To treat the condition of hyponatremia NaCl 3% infusion were used. Whereas, to [treat hyperkalemia conditions furosemid, calcium gluconate, and calcium polystyrene sulfonate drugs were used as single dose or a combination depending on the level.f severity. Sodium and potassium disorders must be treated immediately to prevent the cell damage. The use of ACEI, ARB or a combination is not statistically significant to the emergence of the condition of hyponatremia and hyperkalemia in patients. Based on the results of this study concluded that rugs of choice to treat hyponatremla is NaCl 3% infusion, and for hyperkalemia are furosemide, calcium polystyrene sulfonate and calcium gluconate. There is no effect of the use of ACEI, ARB, or a combination to the emergence of the condition of hyponatremia and hyperkalemia m patients.