CO-PROCESSED} MANITOL-POLIVINIL PIROLIDON (PVP) 30 AND MANITOL-POLYETILEN GLICOL (PEG) 6000 TO IMPROVE COMPACTIBILITY OF MANITOL

• Main Author: Mumtihanah Mursyid, A
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/78939
• Institution: Institut Teknologi Bandung

Background and objectives: Tablet excipients for direct compression should have a good flowability and compactibility. The improvement of excipients properties can be obtained by co-processing method. Mannitol commonly used as a tablet diluents is less hygroscopicity, however it is brittle and has poor flowability and also compactibility. The aim of this research was to improve the flowability and compactibility of manitol by co-processing manflitol with PVP 30 or PEG 6000. Method: Co-processed excipients of mannitol-PVP 30 and mannitol-PEG 6000 were fabricated by wet milling technique. The co-processed material obtained were evaluated for their physical properties such as particle size distribution, average diameter, density, porosity, flowability, compactibility, SEM, PXRD and DTA. Results: The flowability of co-processed mannit01-PVP was higher compared to those of mannitol-PEG, which were in the range of 11.30±0.72 to 12.40±0.50 g/second and 6.40±0.39 to 6.92±0.69 g/second, respectively the tensile strength of co-processed mannitol-PVP was higher compared to those of mannitol-PEG, which were 3.37±0.05 and 2.77±0.07 MPa while both of those co-processed excipients has tensile strength was higher than it's physical mixture, which were 2.48±0.07 and 2.15±0.07 MPa. X-ray diffraction analysis showed that the result of co-processed had similiar pattern with mannitol. The analysis of SEM showed that the tablet made by co-processing technique was more compact. Conclusion: The co-processed mannitol with PVP is more promiyng to use as direct compression material.