ACTIVITY OF COMBINATION OF ETHANOLIC EXTRACT OF KENCUR (KAEMPFERIA GALANGA) RHIZOMES,ROSELLA (HIBISCUS SABDARIFA L) CALYXES, AND RED BETEL (PIPER CROCATUM) LEAVES WITH ANTI-TUBERCULOSIS DRUGS AGAINT MULTI-DRUG RESISTANT MYCOBACTERIUM TUBERCOLOSIS}

• Main Author: Nur Fauziyah, Prabasiwi
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/78969
• Institution: Institut Teknologi Bandung

Tuberculosis is one ofthe deadliest communicable disease in the world. Eradication of tuberculosis still need many works because of adverse drug reaction of antituberculosis drugs and resistancy remain to be the causes to tuberculosis therapeutic failure. This research aimed to find combination effect of standard antituberculosis drugs with Hibiscus Sabdariffa L., Kaempferia galanga L., and Piper crocaium N E. Br against multi-drug resistant (NOR) M. tuberculosis isolates. Two IVIDR strains (i.e. isoniazid-ethambutol resistant and rifampicin-streptomycin resistant) of M tuberculosis were inoculated in Lowenstein—Jensen medium contained with two combination of standard antituberculosis drugs and ethanolic extracts of Hibiscus sabdariffa calyxes, Kaempferia galangal rhizomes, and Piper crocarum leaves using various combination of concentration of drug ahd extract- The colonies number were observed for 8 weeks. The effects of interaction were determined as percentage of inhibition which calculated by mean colonies number on drug-extract containing medium compared to extract-free control medium. Result ofthe research showed that against two IVOR strains of Mycobacterium tuberculosis, all of the plants used in this research had good combination effect with anti-tuberculosis drugs. Overall, combination ofKaempferia galanga L. and all of anti-tuberculosis drugs separately had the best percent of inhibition followed by Hibiscus sabdarifjå and Piper crocatum N.E.