PHARMACOECONOMY ANALYSIS OF INSULIN FOR THE THERAPY OF TYPE 2 DIABETES MELLITUS IN DR. HASAN SADIKIN HOSPITAL BANDUNG
Background and Objectives: Diabetes Melitus (DM) is a complex chronic disease which require continuous medical treatments. Based on data from Riskesdas in year 2013, the prevalence of DM in Indonesia increased from % (year 2007) to 2, 1% (year 2013). Oral hypoglycemic agents have role in decreasing...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/78985 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Background and Objectives: Diabetes Melitus (DM) is a complex chronic disease which require continuous medical treatments. Based on data from Riskesdas in year 2013, the prevalence of DM in Indonesia increased from % (year 2007) to 2, 1% (year 2013). Oral hypoglycemic agents have role in decreasing insulin resistancy or facilitating insulin excretion and effective for early phase of disease. However, most of type 2 DM patients will require insulin therapy eventually. The purpose of this study is to determine insulin therapy's cost effectiveness in type 2 DM in a particular hospital in Bandung. Methods: this is an observational study with retrospective and concu1Tent data which was conducted in RSUP Dr. Hasan Sadikin Bandung. The source documents included drug prescribing records and patient's medical records including laboratory test results. Insulin was chosen as drug to be analyzed, whether as single therapy or combination with any other antidiabetic agents. The cost of therapy were direct cost, which were standardized as per nett price in MIMM$ 2015. The parameter of this study were mean of daily cost during data collection period and mean of fasting glucose and 2 h post-prandial (pp) glucose reduction. Result: based on comparison of each therapeutic groups, insulin aspart showed higher effect in reducing fasting and 2h pp glucose with lower cost compared to insulin aspart premixed. The combination of insulin lispro and glargine showed higher effect in reducing fasting and 2h pp glucose with lower cost compared to other combinations of rapid and long acting insulin. Coclusion: to reduce fasting and 2h pp glucose, the use of insulin aspart was more cost-effective than insulin premixed. Combination of insulin lispro and detemir were advised as the combination of rapid and long acting insulin.
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