PENGARUH NIKOTIN TERHADAP EKSPRESI PUTUS OBAT PADA MODEL HEWAN KETERGANTUNGAN ALKOHOL
Background: Alcohol addiction and dependence have become increasingly serious health and xoblems. Alcohol is frequently co-abused with other addictive drugs. For example, most -.:zs are heavy tobacco users and among non alcoholics, those who smoke consume more ra:pd than those who do not. Involvemen...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/79028 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Background: Alcohol addiction and dependence have become increasingly serious health and xoblems. Alcohol is frequently co-abused with other addictive drugs. For example, most -.:zs are heavy tobacco users and among non alcoholics, those who smoke consume more ra:pd than those who do not. Involvement of arachidonic acid cascade in drug dependence has •plicated in many studies using animal models. Meanwhile the cholinergic system has -o play crucial role in behavioral aspects (including learning and memory) of the central cus system. The aim of this study was to explore the role of cholinergic system and z:.dcnic acid cascade in nicotine-alcohol co-administered animal model of dependence.
: mice were housed individually and 15% ethanol was given every day for 22 days and -rued with nicotin 3 times a day for 5 days. Daily ethanol intake was measured. Twenty five after the cessation of alcoholic drink, each mouse received 10 mg/kg diclofenac (a inhibitor) intraperitoneally to induce withdrawal. The incidents of withdrawal such as fore paw licking, facial preening, grooming and fore paw tremor were observed counted. In addition, forced swim test was conducted to observe any accompaning effect of &awal on depressive behavior. Measurement of brain acetylcholinesterase activity (in vitro) conducted using Ellman's method. Results: Nicotine at 0.25, 0.5 and I mg/kg, was shown to the volume of alcoholic drink consumed. Administration of nicotine resulted in slight in diclofenac-induced duration of grooming, fore paw licking and facial preening. , weight lost and increased acetylcholine esterase activity were significantly observed in eol-nicotine co-administered mice compared to alcohol only-treated mice. Interestingly, -ö)l-induced depressive sign was significantly reduced in groups receiving alcohol-nicotine inistration. Conclusion: It was shown that administration of nicotine affected the ion of alcohol withdrawal in such a way that it improves the central while exaggerates expression, in which the cholinergic system is involved.
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