QSAR, PHARMACOPHORE FEATURES AND MOLECULAR DOCKING STUDY OF PIRAZOLO-[3,4-D]-PYRIMIDINES AS MER TYROSINE KINASE INHIBITOR
Mer receptor tyrosine kinase is ectopically expressed in Acute Lymphoblastic Leukemia (ALL) cell lines, but Mer is not expressed in normal mouse and human T and B-lymphocytes at any stage of development. Inhibition of Mer expression reduces pro-survival signaling, dramatically increases the sensi...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/79068 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |