PENGKAJIAN DRUG RELATED PROBLEMS (DRPS) PADA PENGOBATAN GAGAL GINJAL KRONIS DI RUANG MELATI RS DR. HASAN SADIKIN BANDUNG

• Main Author: Sariwibawa Ahmad Zaeni, Habiba
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/79194
• Institution: Institut Teknologi Bandung

In the clinical treatment of diseases, Drug-Related Problems (DRPs) may occur. Eight categories of DRPs are as follows: the patient has a medical condition that requires drug therapy ( a drug indication) but the patient is not receiving a drug for that indication, for which the wrong drug is being taken, for which too little of the correct drug is being taken, for which too much of the correct drug is being taken, resulting from an adverse drug reaction, resulting from a drug-drug, drug-food or drug-laboratory interaction, that is the result of not receiving the prescribed drug (non-adherence), and that is the result of taking a drug for which there is no valid medical indication (accidental or intentional poisoning) (Strand et.al.). Risk factors of DRPs are those of polipharmacy, multi patient’s disease statuses, low compliance history, use of drugs that need therapeutic monitoring, twelve or more drug doses daily, and four or more changes in the drug regimen during the last 12 months. Chronic Kidney Disease (CKD) is defined as a progressive loss of renal function, occurring over months or years and is characterised with the gradual replacement of normal kidney architecture by interstitial fibrosis. Patients with CKD stadium V or ESRD (End Stage Renal Disease) are prescribed on average of 10-12 treatments. The purpose of this study is to identify DRPs of the CKD patients. A retrospective study with observationally descriptive design was undertaken to 47 patients hospitalised for chronic kidney disease at the Melati Ward, Dr Hasan Sadikin General Hospital during the period of August 2009 to October 2009. The study results revealed that 19% of cases requiring a drug therapy, 20% requiring drug therapy with no medical indication, 7% for which the wrong drug is being taken, 16% for which too much or less of the correct drug is being taken, and 37% of cases with probably drug-drug interaction. No statistically significant differences were found between the number of patients’ comorbid(s) and of DRPs (F(9.37) = 0,642; P<0,05). Statistically significant differences were, however, found between patients’ stadium of CKD and the number of DRPs.