PENANGANAN EFEK SAMPING TERAPI LUPUS ERITEMATOSUS SISTEMIK DI RSUP DR. HASAN SADIKIN BANDUNG

• Main Author: Pury Oktora, Monika
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/79217
• Institution: Institut Teknologi Bandung

Systemic lupus erithematosus (SLE) is an autoimmune disease which is manifestated by organs and cells damaged caused by tissue binding autoantibody and immune complex deposited. Therapy for lupus is long term therapy with a variuos of adverse effect among individuals and can be fatal if the treatment is not appropiate. The objective of this research is to determine the adverse effects of the drugs that used to treat SLE and the treatment of the adverse effects. This research was done by cross sectional and retrospective studies, by using medical record data of in- and outpatients at Hasan Sadikin Hospital (RSHS) Bandung. Result showed that adverse effects that occured for outpatients during therapy with methyl prednisolon were hypertension (18.03%), hyperlipidemia (9.02%), moon face (4.92%), facial flushing (0.82%), miositis (0.82%), gastrointestinal disruption (25.41%), myelosupression (0.82%), and changing in eye refraction (1.64%); with chloroquine: maculopathy (2.54%); with azathioprin: myelosupression (4.35%); with cyclophosphamide: myelosupression (9.09%); with mycophenolat mofetil: myelosuppresion (2.94%), gastrointestinal disuption (2.94); with methyl prednisolonmycophenolat mofetil: gastrointestial disruption (50%); For inpatients, the adverse effect caused by therapy with methyl prednisolon were hypertension (20%), hyperlipidemia (8%), hyperglicemia (4%), cushing syndrome (4%), steroid gastropathy (24%), gastroenteritis (50%), stress ulcer (4%); caused by mycophenolat mofetil: gastroenteritis (50%); caused by combination of methyl predisolon-mycophenolat mofetil: stress ulcer (4%). The treatment of those adverse effects were preventive and curative, i.e., with calsium, vitamin D, and folic acid, for preventive with antiulcer agents and acid secretion suppressants, hypotensive agent, antilipilemic agents, antidiabetic agen for curative; antibiotic for comorbid infection, eye examination, and decreasing or stopping the drug dose if the adverse effects were not tolerable. In general, the treatment of adverse effects during therapy of SLE in- and outpatients at RSHS was proper with theory, however the anticipating treatment for osteoporosis need to be further improved because not all the patients have access to get vitamin D or biphosphonate.