IDENTIFIKASI JENIS INTERAKSI SISTEM BINER FENOBARBITAL DAN ISOPROPILANTIPIRIN MELALUI METODA TERMAL

• Main Author: Wiryani, Jessica
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/79229
• Institution: Institut Teknologi Bandung

In pharmaceutical dosage forms, combination of two or more active substances is commonly used. The usage of this combination potentially exhibited problems in the manufacturing due to the physical interaction between the two materials, especially for compounds that have similar crystal lattice. Therefore, this study was carried out to identify the type of the occured interactions on a combination of two active ingredients, i.e phenobarbital and isopropylantipyrine. Physical mixtures were prepared in molar combination of phenobarbital and isopropylantipyrine (0.02:0.98), (0.075:0.925), (0.3:0.7), (0.5:0.5), (0.7:0.3) and (0.9:0.1). Melting point of the mixture was determined using thermal analysis method, hot stage polarizing microscope, electrothermal and Differential Scanning Calorimetry (DSC), whilst the X-ray diffraction and Scanning Electron Microscope (SEM) were applied in order to identify and confirm the termal analysis results. Obtained data from thermal analysis was used to construct a phase diagram of binary systems. Results from phase diagrams was compared to the observation of the contact methods on the polarizing microscope. The result was molecular compound melt congruently at 160ºC with two eutectic points at E1 = 102°C and E2 = 156°C. Both thermal analysis and contact method showed identical results, namely congruently melted molecular compound has been formed. Molecular compound has been formed in the mixture of 0.5 molar with a melting point at 160°C. Resulted molecular compound shows the new interferences on diffractogram of X-ray diffraction and new habit on the microphoto of Scanning Electron Microscope (SEM) method.