PENINGKATAN LAJU DISOLUSI NIFEDIPINE DENGAN PEMBENTUKAN KOMPLEKS INKLUSI Î’-SIKLODEKSTRIN

• Main Author: Permata Sari, Citra
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/79235
• Institution: Institut Teknologi Bandung

Nifedipin is included in the class of drugs with poor solubility in water and slow dissolution rate, consequently it can influence its bioavailability. The purpose of this research were to increase dissolution rate by developing a nifedipin inclusion complex with ?-cyclodextrin and to compare the dissolution rate of nifedipin from inclusion complex loaded-tablets with nifedipin tablets which were developed by direct compression and wet granulation. In this research was be made Nifedipin-inclusion complexes with ?-cyclodextrin by mole ratio of 1:1 and 1:4 were prepared by cogrinding and coprecipitation methods. The inclusion complexes were evaluated by SEM (Scanning Electron Microscopy), X-ray diffraction and dissolution testing. Furthermore, the inclusion complexes were incorporated in tablet dosage which were prepared by direct compression and wet granulation. Tablets inclusion complexes then evaluated, included organoleptic test, chemical-physically test, weight variation, uniformity test, determination of active substance assay by spectrophotometry UV and dissolution test. The dissolution testing revealed increasing the released nifedipin from tablets in period of 120 minutes and the highest increasing dissolution was showed by inclusion complex tablet on mole ratio nifedipin : ?siklodekstrin = 1:4. Meanwhile in terms of tablet manufacturing method, highest changes in dissolution rates occured in wet granulation methods. Based on the results of this study, it can be concluded that inclusion complex could improve the released nifedipin from tablet.