MATHEMATICAL MODEL OF IMMUNE RESPONSE MEDIATED BY ANTIBODY TO DENGUE VIRUS INFECTION
Dengue fever is a viral mosquito-borne infection and a major international public health concern. With 2.5 billion people at risk of acquiring the infection around the world, disease severity is influenced by the immunological status of the individual, seronegative or seropositive, prior to natur...
Saved in:
| Main Author: | |
|---|---|
| Format: | Dissertations |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/79859 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Dengue fever is a viral mosquito-borne infection and a major international public
health concern. With 2.5 billion people at risk of acquiring the infection around the
world, disease severity is influenced by the immunological status of the individual,
seronegative or seropositive, prior to natural infection. Caused by four antigenically
related but distinct serotypes, DENV-1 to DENV-4, infection by one serotype
confers life-long immunity to that serotype and a period of temporary crossimmunity
(TCI) to other serotypes. The clinical response on exposure to a second
serotype is complex with the so-called antibody-dependent enhancement (ADE)
process, a disease augmentation phenomenon when pre-existing antibodies to
previous dengue infection do not neutralize but rather enhance the new infection,
used to explain the etiology of severe disease.
This dissertation present a minimalistic mathematical model framework developed
to describe qualitatively the dengue immunological response mediated by
antibodies. Three models are analyzed and compared: (i) primary dengue infection,
(ii) secondary dengue infection with the same (homologous) dengue virus and (iii)
secondary dengue infection with a different (heterologous) dengue virus. The model
analyze by exploring the features of viral replication, antibody production and
infection clearance over time. The model is developed based on body cells and
free virus interactions resulting in infected cells activating antibody production
Mathematical results are qualitatively similar to the ones described in the empiric
immunology literature, providing insights into the immunopathogenesis of severe
disease. Results presented here are of use for future research directions to evaluate
the impact of dengue vaccines |
|---|