EVALUASI EFEK ANTIRADANG EKSTRAK ETANOL PERIKARPIUM BUAH MAHKOTA DEWA (PHALERIA MACROCARPA (SCHEFF.) BOERL.), EKSTRAK METANOL KAYU SAPPAN (CAESALPINIA SAPPAN L.), DAN KOMBINASINYA PADA TIKUS BETINA GALUR WISTAR
Phaleria macrocarpa and Caesalpinia sappan have been used in traditional cure as antiinflammatory. In vitro assay for isolates of sappan heartwood anti-inflammatory activity has been reported. This study aims to evaluate the anti-inflammatory effect of single extracts, ethanol extract of pericar...
Saved in:
| Main Author: | |
|---|---|
| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/80545 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Phaleria macrocarpa and Caesalpinia sappan have been used in traditional cure as antiinflammatory. In vitro assay for isolates of sappan heartwood anti-inflammatory activity
has been reported. This study aims to evaluate the anti-inflammatory effect of single
extracts, ethanol extract of pericarp of mahkota dewa and methanol extract of sappan
heartwood, and combination effect of both extracts. Simplicia used in this experiment are
dried pericarp of mahkota dewa and sappan heartwood. Mahkota dewa pericarp and sappan
heartwood were extracted using reflux method. Anti-inflammatory assay include
observation in redness index, swelling, and walking activity in inflammatory sodium urateinduced rat. Ethanol extract of mahkota dewa pericarp 22,5 mg/kg bb and methanol extract
of sappan lignum 63,9 mg/kg bb showed anti-inflammatory effect, but combination of
extracts did not perform a better effect. Ethanol extract of mahkota dewa pericarp reduced
redness index significantly (p<0.05) on forth and seventh day. Methanol extract of sappan
lignum and combination extract reduced redness index significantly (p<0.05) on seventh
day. From the third day, combination of extracts reduced walking activity significantly
(p<0.05). Single extract reduced walking activity significantly (p<0.05) from forth day.
Ethanol extract of mahkota dewa pericarp 22,5 mg/kg bb, methanol extract of sappan
lignum 63,9 mg/kg bb and combination of extracts reduced swelling significantly (p<0.05)
from the fifth day. Combination of extracts didn’t differ significantly from both, ethanol
extract of mahkota dewa pericarp 22,5 mg/kg bb and methanol extract of sappan lignum
63,9 mg/kg bb |
|---|