SINTESIS SENYAWA - SENYAWA ANTARA VINILOG KURKUMINOID
The synthesis of curcuminoid vinylogue intermediates through the transformation and degradation of functional groups was done by using piperine as the starting material which acted as the relay point of the synthetic plan proposed. Piperine as a starting material was isolated from the dried ripe fru...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/8183 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | The synthesis of curcuminoid vinylogue intermediates through the transformation and degradation of functional groups was done by using piperine as the starting material which acted as the relay point of the synthetic plan proposed. Piperine as a starting material was isolated from the dried ripe fruit of Piper nigrum L., Piperaceae (blacX pepper). The piperine content of the fruit was 4.1 %. The curcuminoid vinilogue intermediates which were synthesized in this respect are: Piperic acid which was acquired through the hydrolysis of piperine using 10% ethanolic KOH with a 97.8% yield. Piperoyl diethyl malonate, as a result of the reaction between piperoyl chloride and the organomagnesium of ethyl malonate with a yield of 40.13%. Piperoil chloride as the acyl chloride of its carboxylate, piperic acid, was acquired through the action of thionyl chloride to the carboxylate. Ethyl piperoil acetate was targeted as a result of a partial basic or acidic hydrolysis of the diethyl piperoil malonate. Structure elucidation of the synthesized compounds through spec troscopic determinations, UV, IR, 1HN and 13C , MS, and also ele mental analysis, concluded that the compounds in respect could be differentiated from its parent compounds.
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