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Ganglia basa is part of the brain which plays important role balancing motoric pathways. One of diseases caused by disability of ganglia basalis is Parkinson. This neurodegenerative diseased caused by deficit of dopamine which is produced by Substantial Nigra pars compacta (SNpc) in the ganglia basa...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/8197 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Ganglia basa is part of the brain which plays important role balancing motoric pathways. One of diseases caused by disability of ganglia basalis is Parkinson. This neurodegenerative diseased caused by deficit of dopamine which is produced by Substantial Nigra pars compacta (SNpc) in the ganglia basalis. This M will reduce activities of Globus Palidus Externa (GPe) and increase activities of Subthalamic Nucleus (STN), which may cause Parkinson Syndromes. The signal process in (ganglia basalis is as follows: GPe will inhibit STN and STN will excitate GPe. Here the communication process, between STN and GPe cells is being modeled. The model is developed from Hodkin-Huxley model, taking into account the influence of calcium, Dynamical analysis using Matcont shown for single STN cell and single GPd cell. Further, the analysis will be made for the relation of two STN and two GPd cells. In this relation, the communication between STN and GPe depend on degree of synaptic conductance. This result will give benefits in development of Parkinson disease treatment. <br />
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