SEDATIVE HYPNOTIC EFFECT OF ETHANOL EXTRACT OF BASIL (OCIMUM AMERICANUM L.) LEAVES IN MALE SWISS WEBSTER MICE
Sleep is important for human health because the body and brain recover and process important information; Insomnia is a common sleep disorder, characterized by frequent awakenings at night and difficulty falling back asleep; Conventional treatment with sedative hypnotics can be used to treat inso...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/82337 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Sleep is important for human health because the body and brain recover and process important
information; Insomnia is a common sleep disorder, characterized by frequent awakenings at night
and difficulty falling back asleep; Conventional treatment with sedative hypnotics can be used to
treat insomnia, but they could cause side effects, tolerance and dependence; Therefore, this study
aims to test the hypnotic and sedative effects of basil leaf extract; Basil leaf extract was obtained
using the maceration method with a ???ethanol solvent; Evaluation of the hypnotic effect involved
measuring the latency, duration, and efficiency of sleep, as well as the dorsal temperature of the
mice, which were induced to sleep with ?mg diazepam?kg BW; The results showed that the addition
of ethanol extract of basil leaves at doses of ???, ???, ???mg?kg BW after induction with diazepam
accelerated sleep latency, lengthen sleep duration, increased sleep efficiency, and reduced the
dorsal temperature of mice; The ethanol extract of basil at a dose of ???and ???mg?kg BW showed
the shortest sleep latency ??;?minutes ?????;??and ?;?minutes ?????;???, the ethanol extract of basil
at a dose of ???mg?kg BW showed the longest sleep duration ????;?minutes ?????;???and basil
ethanol extract at a dose of ???mg?kg BW showed the greatest sleep efficiency ???;????????;????;
In testing the sedative effect, the ethanol extract of basil leaves at a dose of ???mg?kg BW showed
the most potent effect in reducing the response to stimulus and ptosis; The ethanol extract of basil
leaves at ???mg?kg BW had significantly different sedation scale compared to the vehicle ?CMC?
Na?; In conclusion, the ethanol extract of basil leaves at ???mg?kg BW showed the most potent
sedative effect, while all extract treatment produced escalating hypnotic effect, after induction with
?mg?kg BW diazepam;
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