DRUG INTERACTION ANALYSIS IN THE CASE OF CONGESTIVE HEART FAILURE (CHF)AT INPATIENT ROOM OF POLICE HOSPITAL SARTIKA ASIH BANDUNG CITY

• Main Author: Dinar Hudaya, Luthfi
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/82428
• Institution: Institut Teknologi Bandung

Congestive Heart Failure or CHF is a complex abnormal heart condition that causes the heart unable to pump the blood as the body needs. The aim of this study was to identify and appraise the occurrence of potential and actual drug interaction-related problems in CHF patients with or without comorbid diseases. The method of research used was descriptive non-experimental research with a prospective cross-sectional design by prospectively monitoring patient medical record data during October 2023 - December 2023.The sampling technique used non-probability sampling method, with total sampling of 100 patients. Inclusion criteria were new patients hospitalized with diagnose of CHF with or without comorbid diseases, patients with total medication in 1 prescription form of more than 1 (one) drug. Exclusion criteria included patients with incomplete or unreadable medical records. Drug interaction classification was analyzed by Dynamed-Micromedex 2022 Version 3.0.4 (5070) and Medscape Interaction checker. Results of the research found that the highest number of comorbidities with the percentage of 44.55% was Hypertensive Heart Disease (HHD). HHD is a disease related to secondary effects on the heart because prolonged systemic hypertension leads to complications in the form of Left Ventricle Hypertrophy (LVH), which will manifest clinically as congestive heart failure. The most potential interaction analysis of 100 patients was aspirin and furosemide 34 cases (8%) with pharmacodynamic interaction and major severity interaction. While the actual interaction analysis that occurred in 15 patients was digoxin and furosemide in 5 patients with pharmacodynamic interaction and major severity interaction. Therefore, from the potential and actual interactions, the most common is pharmacodynamic interaction with major severity interaction.