THE EFFECT OF METOCLOPRAMIDE HYDROCHLORIDE COCRYSTALLIZATION WITH OXALIC ACID COFORMER ON TABLET DISSOLUTIONÂ PROFILE
Metoclopramide hydrochloride (MCPHCl) can change to anhydrous at a temperature of 70°C and return to monohydrate at a humidity of 65%-75% RH. Previous research successfully co-crystallized MCPHCl with oxalic acid (OXA), producing a form with higher thermodynamic stability and a lower intrinsic di...
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Format: | Final Project |
Language: | Indonesia |
Online Access: | https://digilib.itb.ac.id/gdl/view/82430 |
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Institution: | Institut Teknologi Bandung |
Language: | Indonesia |