RISK FACTORS OF HEMATOTOXICITY DURING MAINTENANCE PHASE OF CHEMOTHERAPY IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS AT AL-ISLAM HOSPITAL BANDUNG

• Main Author: Natasha B M I F, Faizureen
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/82576
• Institution: Institut Teknologi Bandung

Treatment for acute lymphoblastic leukemia in pediatric patients is lengthy and demanding, often resulting in adverse drug reactions. Acute lymphoblastic leukemia (ALL) is a prevalent malignancy among pediatric patients, characterized by abnormal proliferation and differentiation of lymphoid cells. This study aims to identify risk factors contributing to hematotoxicity during the maintenance phase of chemotherapy, focusing on 6-mercaptopurine (6-MP) and methotrexate (MTX) administration, crucial for eliminating residual leukemic clones and preventing relapse. Clinical presentation of hematotoxicity during maintenance therapy may manifest with non-specific constitutional signs and symptoms, including leukopenia, anemia, and thrombocytopenia. We conducted a retrospective cohort study at Al-Islam Hospital, Bandung, collecting clinical data on hemoglobin, platelet, and neutrophil counts. The severity of hematotoxicity was assessed using the Common Terminology Criteria for Adverse Events (CTCAE) v5.0 grading scale. Statistical analysis was performed using Minitab Statistical Software. Bivariate analysis revealed no significant differences between anemia and various variables such as age, gender, nutritional status, stratification risk, and body mass index (p = 0.730, p = 0.304, p = 0.171, p = 0.078, p = 0.408). Similarly, platelet count showed no significant differences concerning age, gender, nutritional status, stratification risk, and BMI (p = 0.919, p = 0.418, p = 0.349, p = 0.859, p = 0.657). Neutrophil count analysis also demonstrated no significant associations with age, gender, and nutritional status (p = 0.870, p = 0.126, p = 0.627, p = 0.158, p = 0.985). In summary, none of the findings indicate a notable variance between the risk factors and hematotoxicity. ?