SYNTHESIS AND CHARACTERIZATION OF BIPHASIC CALCIUM PHOSPHATE/13?93 BIOACTIVE GLASS MIXTURE

• Main Author: Dindra Azzam Cendekia, Fa'iq
• Format: Final Project
• Language: Indonesia
• Subjects: Kimia
• Online Access: https://digilib.itb.ac.id/gdl/view/83333
• Institution: Institut Teknologi Bandung

Biphasic calcium phosphate (BCP) is a material widely used in healthcare, particularly in dental and bone-related applications. BCP is utilized for bone grafts, dental fillings, bone substitutes, and drug delivery due to its excellent bioactivity and biocompatibility. The addition of additives can alter the chemical and physical properties of BCP, making its application more optimal. Bioactive glass (BG) is one such additive that can be mixed with BCP to produce dental filling materials. 13?93 BG is a BG with a composition of 53SiO2; 6Na2O; 20CaO; 4P2O5; 12K2O; dan 5MgO (%w/w). BG can enhance mechanical strength and antibacterial properties. BCP, a member of the calcium phosphate compounds group, consists of hydroxyapatite (HA) and ?-tricalcium phosphate (?-TCP) in varying compositions. In this study, BCP was successfully synthesized from a mixture of Ca(NO3)2 and (NH4)2HPO4 solutions using the sonochemical method. The reaction was carried out at a solution pH of 10?11 and a temperature of 60 °C for 2 hours. BCP was synthesized with varying mol ratios of Ca/P (1.50?1.67) to study the effect of the Ca/P ratio on the HA and ?-TCP phases in the formed BCP material. At a mol ratio of Ca/P = 1.52, an HA/?-TCP composition close to 30/70 was obtained, analyzed using powder X-ray diffraction (PXRD). Meanwhile, 13?93 BG was synthesized using the sol-gel method at room temperature. BCP was mixed with 13?93 BG using the mechanical mixing method, with BG added at 2.5% and 5% w/w. The addition of 13?93 BG to BCP resulted in an increase in the HA phase, as analyzed from PXRD data. The bioactivity of the resulting BCP and BCP/13?93 BG products was tested by immersion in simulated body fluid (SBF) for 15 days. Scanning electron microscope-energy dispersive X ray spectroscopy (SEM-EDS) results showed that the BCP/13?93 BG sample had a similar morphology to BCP, with a spherical shape and particle sizes ranging from 100?1.000 nm. After immersion in SBF, a new layer likely composed of apatite formed on the surface of BCP and BCP/13?93 BG samples. SEM-EDS results also indicated changes in the levels of alkali and alkaline earth metals on the surface of BCP/13?93 BG after immersion in SBF. These results indicate that BCP/13?93 BG has good bioactivity.