THE EFFECT OF SR2+ AND AG+ MODIFIED HYDROXYAPATITE ON PHASE COMPOSITION OF BIPHASIC CALCIUM PHOSPHATE
The results of the “Riset Kesehatan Dasar 2018” conducted by the Indonesian Ministry of Health showed that as many as 88,8% of the Indonesian population experienced cavities, with 93% of them being children aged 5-6 years. Therefore, the need for safe, durable and cheap dental filling or impla...
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| Format: | Final Project |
| Language: | Indonesia |
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| Online Access: | https://digilib.itb.ac.id/gdl/view/83335 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | The results of the “Riset Kesehatan Dasar 2018” conducted by the Indonesian Ministry of
Health showed that as many as 88,8% of the Indonesian population experienced cavities, with
93% of them being children aged 5-6 years. Therefore, the need for safe, durable and cheap
dental filling or implant materials needs to be provided. One of the components of this material
is a calcium phosphate-based compound, which consists of several types, including
hydroxyapatite (HA), ?-tricalcium phosphate (?-TCP), etc. The combination of
hydroxyapatite (HA) with ?-tricalcium phosphate (?-TCP) produces a composite named
biphasic calcium phosphate (BCP). To improve the physical or chemical properties of BCP to
suit for needs, one effort that can be made is to modify the composition of the BCP. One of
the compounds that make up BCP, namely HA, is modified by adding cations. The aim of this
research is to study the effect of Sr2+ and Ag+ modified HA on the percentage phase
composition of BCP material, which is synthesized using the mechanochemical method at
room temperature. Modified HA and ?-TCP were each synthesized by the sol-gel method,
with the help of citric acid. The products produced in this research were labeled BCP, BCPSr,
BCPAg, and BCPSrAg, respectively. BCP was prepared from a mixture of HA:?-TCP with a
molar percentage ratio of 70:30 and using a mechanical mixing method at room temperature.
The results of Powder X-Ray Diffraction (PXRD) characterization results showed that Sr2+
ions caused an increase in the lattice parameters of BCP and an increase in the percentage of
HA in the BCPSr sample, which was compared with BCP. Furthermore, the presence of Ag+
ions caused a decrease in the percentage of the HA phase, followed by an increase in the ?
TCP phase in the BCPAg sample. In the PXRD diffractogram, the BCPSrAg sample observed
a decrease in the percentage of HA phase, but less than in the BCPAg sample. Preliminary
antibacterial studies show that samples BCPAg and BCPSrAg can inhibit the growth of
Staphylococcus aureus and Escherichia coli bacteria. |
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