DEVELOPMENT OF PLA/HA COMPOSITE FOR BONE IMPLANT APPLICATIONS

The global market for orthopedic implants is predicted to be worth USD 48 billion in 2022, rising to USD 72.08 billion by 2032. Despite the effectiveness of current supplies and technology, implant materials have substantial limitations in terms of physical and biochemical compatibility with surroun...

Full description

Saved in:
Bibliographic Details
Main Author: Faza Zakiyyah, Yasmin
Format: Final Project
Language:Indonesia
Online Access:https://digilib.itb.ac.id/gdl/view/84919
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Institut Teknologi Bandung
Language: Indonesia
id id-itb.:84919
spelling id-itb.:849192024-08-19T10:16:13ZDEVELOPMENT OF PLA/HA COMPOSITE FOR BONE IMPLANT APPLICATIONS Faza Zakiyyah, Yasmin Indonesia Final Project Orthopedic implants, PLA/HA, solvent and solvent-free techniques, mechanical characterization INSTITUT TEKNOLOGI BANDUNG https://digilib.itb.ac.id/gdl/view/84919 The global market for orthopedic implants is predicted to be worth USD 48 billion in 2022, rising to USD 72.08 billion by 2032. Despite the effectiveness of current supplies and technology, implant materials have substantial limitations in terms of physical and biochemical compatibility with surrounding bone. Polymer/bioceramic composites, particularly degradable polylactide and hydroxyapatite (PLA/HA) composites, have lately emerged as a promising option that closely mimics real bone. It has been established that adding HA to the PLA matrix enhances the physical and mechanical properties of the composite material. The research aims to develop an efficient processing route for PLA/HA to achieve desired shape and mechanical properties, aiming to replace current bone implant materials with a more biocompatible, stable, and effective alternative. This is achieved using the solvent and solvent-free techniques. Mechanical characterization of the composite is determined through compressive strength test and bending strength test. The study confirms that dichloromethane is the best solvent for dissolving PLA/HA mixtures. Three solvent-free methods were attempted: filament extrusion, injection molding, and oven melting. Mechanical testing showed that bending strength increases with higher HA content, but there were significant deviations due to differences in sample thickness and DCM quantity. The average bending strength of the 10% and 30%-HA samples are 31.29 MPa and 75.91 MPa respectively. The average compressive strength of the 10% and 30%-HA samples are 2.03 MPa and 1.41 MPa respectively. The study indicates that uniform sample structures produced through compacting manufacturing methods like injection molding, uniaxial pressing, and FDM 3D printing and filament extrusion enhance bending and compressive strengths. text
institution Institut Teknologi Bandung
building Institut Teknologi Bandung Library
continent Asia
country Indonesia
Indonesia
content_provider Institut Teknologi Bandung
collection Digital ITB
language Indonesia
description The global market for orthopedic implants is predicted to be worth USD 48 billion in 2022, rising to USD 72.08 billion by 2032. Despite the effectiveness of current supplies and technology, implant materials have substantial limitations in terms of physical and biochemical compatibility with surrounding bone. Polymer/bioceramic composites, particularly degradable polylactide and hydroxyapatite (PLA/HA) composites, have lately emerged as a promising option that closely mimics real bone. It has been established that adding HA to the PLA matrix enhances the physical and mechanical properties of the composite material. The research aims to develop an efficient processing route for PLA/HA to achieve desired shape and mechanical properties, aiming to replace current bone implant materials with a more biocompatible, stable, and effective alternative. This is achieved using the solvent and solvent-free techniques. Mechanical characterization of the composite is determined through compressive strength test and bending strength test. The study confirms that dichloromethane is the best solvent for dissolving PLA/HA mixtures. Three solvent-free methods were attempted: filament extrusion, injection molding, and oven melting. Mechanical testing showed that bending strength increases with higher HA content, but there were significant deviations due to differences in sample thickness and DCM quantity. The average bending strength of the 10% and 30%-HA samples are 31.29 MPa and 75.91 MPa respectively. The average compressive strength of the 10% and 30%-HA samples are 2.03 MPa and 1.41 MPa respectively. The study indicates that uniform sample structures produced through compacting manufacturing methods like injection molding, uniaxial pressing, and FDM 3D printing and filament extrusion enhance bending and compressive strengths.
format Final Project
author Faza Zakiyyah, Yasmin
spellingShingle Faza Zakiyyah, Yasmin
DEVELOPMENT OF PLA/HA COMPOSITE FOR BONE IMPLANT APPLICATIONS
author_facet Faza Zakiyyah, Yasmin
author_sort Faza Zakiyyah, Yasmin
title DEVELOPMENT OF PLA/HA COMPOSITE FOR BONE IMPLANT APPLICATIONS
title_short DEVELOPMENT OF PLA/HA COMPOSITE FOR BONE IMPLANT APPLICATIONS
title_full DEVELOPMENT OF PLA/HA COMPOSITE FOR BONE IMPLANT APPLICATIONS
title_fullStr DEVELOPMENT OF PLA/HA COMPOSITE FOR BONE IMPLANT APPLICATIONS
title_full_unstemmed DEVELOPMENT OF PLA/HA COMPOSITE FOR BONE IMPLANT APPLICATIONS
title_sort development of pla/ha composite for bone implant applications
url https://digilib.itb.ac.id/gdl/view/84919
_version_ 1822998824891711488