SAFETY USE OF COMBINATION TENOFOVIR-LAMIVUDINE-DOLUTEGRAVIR COMPARED WITH TENOFOVIR-LAMIVUDINE-EFAVIRENZ IN HIV PATIENTS AT IBRAHIM ADJIE COMMUNITY HEALTH CENTER BANDUNG

• Main Author: Zidan Fikri Akromy, Muhammad
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/85296
• Institution: Institut Teknologi Bandung

Human immunodeficiency virus (HIV) is a virus that attacks certain of the body's defense systems, causing a weakened immune system and making the body susceptible to infection. Therefore, antiretrovirals (ARV) are needed for HIV patients such as tenofovir, lamivudin, and efavirenz (TLE) or new regimen tenofovir, lamivudin, and dolutegravir (TLD) regimens which have been used in Indonesia since 2021. The objective of this study was to identify and assess the relationship between adherence and adverse drug reactions (ADRs) on quality of life in patients taking a fixed-dose combination regimen of tenofovir, lamivudine, and dolutegravir (TLD), tenofovir, lamivudine, and efavirenz (TLE), and TLE switched to TLD (TLE?TLD). The study was an analytical observational study with a crosssectional design that evaluated patient adherence, patient quality of life, and ADR events during the period from March to May 2024. The sampling technique used was a consecutive sampling method. Inclusion criteria were patients who had been taking the TLD or TLE regimen for more than 3 months, while exclusion criteria were patients who were unable to communicate and pregnant patients. Adherence was assessed using the pill count method, quality of life was assessed using the WHOQoL-HIV BREF questionnaire, and ADR events were assessed using patient interviews. Based on the analysis results in 152 patients, the number of patients with a high level of adherence was 70.39%, with QoL ranked from highest to lowest in social, psychological, physical, independence, environmental and spiritual conditions. The number of HIV patients who experienced ADR events was 40 patients out of 152 patients (26.3%). From this study, the highest quality of life of patients based on adherence criteria was in the group with high adherence to each regimen. While the highest incidence of ADR was in the TLE regimen and the TLE?TLD with 22 of 69 patients (31,8%). The highest quality of life of patients in general was in the TLE?TLD regimen.