FORMULATION AND CHARACTERIZATION OF ROSEMARY (ROSMARINUS OFFICINALIS L.) NANOEMULSION EXTRACT IN ROSEMARY OIL

• Main Author: Wulandari Setiawan, Shakeela
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/85377
• Institution: Institut Teknologi Bandung

Androgenetic alopecia (AGA) is a common hair condition found in both men and women. AGA is triggered by the hormone dihydrotestosterone (DHT), which is the active form of testosterone activated by 5-?????±­?®?¬?±?????????? ®¬???????ã ?í± ?±??ã±??í¬?± (?í± ?±??ð?ã ?í¬?±)????í±?±»??±????±??±??¬? antioxidants are needed to block the release of DHT and neutralize reactive oxygen species (ROS). As an alternative solution, rosemary (Rosmarinus officinalis L.) is a plant rich in secondary metabolites with antioxidant properties. Rosemary leaves are formulated as a nanoemulsion to act as an external antioxidant. The aim of this study is to develop an optimal formula of rosemary extract in rosemary oil by optimizing the concentrations of extract, oil, and surfactant, as well as optimizing the duration and amplitude of the probe sonicator. The characterization of the rosemary extract nanoemulsion was also conducted. The optimal formula was obtained with a composition of 2% (w/v) rosemary ethanol extract, 2% (w/v) rosemary oil, 1,8% (w/v) Tween 80, 1,2% (w/v) propylene glycol, 1% (w/v) hexylene glycol, 1% (w/v) phenoxyethanol, 1% (w/v) menthol, and distilled water up to 100% (w/v). The organoleptic characteristics were clear orange color, a characteristic aromatherapy scent, liquid consistency, with a globule size of 233,65±15,48 nm, polydispersity index of 0,36±0,02, zeta potential of -17,90±0,61 mV, pH of 5,33±0,17, viscosity of 1.114±0,127 P, antioxidant activity with a %inhibition of 63,92%, and it showed the best stability at a storage temperature of 25 C