#TITLE_ALTERNATIVE#
Polyvinylpyrrolidone, Amprotab, Ac-di-sol, NaCMC and Avicel PH 102 had been used as the excipients of mefenamic acid tabletting processes by meansof wet granulation method. <br /> <br /> <br /> It was found thatysical properties as well as the dissolution profile of mefenamic aci...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/8539 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Polyvinylpyrrolidone, Amprotab, Ac-di-sol, NaCMC and Avicel PH 102 had been used as the excipients of mefenamic acid tabletting processes by meansof wet granulation method. <br />
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It was found thatysical properties as well as the dissolution profile of mefenamic acid tablets was affected by the addition of those excipients. The dissolution rates and the physical characteristics of mefenamic acid tablets were enhanced after using polyvinylpyrrolidone as a binder, Avicel PH 102 and Ac-di-sol as disintegrator. The dissolution test had been carried out in phosphate buffer medium at pH 7,4 and at a temperature of 37 + 0,5 oC. The paddle stirrer rotated at 50 rpm. <br />
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Bioavailability tests had been done for two tablets formulas of mefenamic acid which showed a great difference in their dissolution rates. Four heal., men volunteered for the bioavailability test. The result showed that no relation-ship existed between the dissolution rate of the tablet and its bioavailability under those conditions. <br />
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