THE EFFECTS OF USING GOLD NANOPARTICLE ON TUMOR DOSE IN RADIATION THERAPY BASED ON MONTE CARLO SIMULATION

• Main Author: Sri Wardifa, Annisa
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/85834
• Institution: Institut Teknologi Bandung

Radiotherapy is an important method in tumor treatment to destroy tumor cells using ionizing radiation. However, it can also result in damage to normal tissues around the tumor. One solution to this problem is to add high atomic number materials to the tumor such as gold nanoparticles. These materials can induce higher toxicity in tumor cells than normal cells. In addition, gold nanoparticles can increase the radiation dose because they have a high mass attenuation coefficient and biocompatibility. In this study, a Monte Carlo simulation using the EGSnrc was performed to see the effect of using gold nanoparticles on tumor dose distribution. A cube-shaped phantom with a size of 20 ???? 20 ???? 20 ????????3 was simulated and a tumor with a dimension 2 ???? 2 ???? 2 ????????3 located at a depth of 2 ???????? below the phantom surface. Two variations of photon energy were used, 2 MeV and 6 MeV. The phantom was irradiated at a distance of 100 cm from the source with a field size 2 ???? 2 ????????2. In the tumor volume, gold nanoparticles were added as homogeneous mixture. The results show that the addition of gold nanoparticles with the use of higher photon energy can increase the dose received by the tumor with an increase of 1,162. The factor that affects the increase in tumor dose is the concentration of gold nanoparticles. Two variations of gold nanoparticle concentrations were used, 7 mg/g and 18 mg/g. Increasing the concentration of gold nanoparticles by 2,571 times caused an increase in dose by 0.499%-7.899%. Increasing the concentration of gold nanoparticles causes more photoelectric interactions between photons and gold atoms so that the resulting energy deposition increases.