DESIGN OF A BRAIN BLOOD VESSEL PHANTOM WITH INTRACRANIAL ANEURYSM AS A LEARNING MEDIUM FOR INTERVENTION PROCEDURES

• Main Author: Mona Farhany, Indira
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/86166
• Institution: Institut Teknologi Bandung

Intracranial aneurysm is a medical condition associated with a high mortality rate, with approximately 50% of patients diagnosed with intracranial aneurysms and experiencing subarachnoid hemorrhage following aneurysm rupture ultimately succumbing to the condition. The coiling procedure is the recommended intervention for treating this condition. However, the limited availability of training in coiling techniques has led to its underutilization in the management of intracranial aneurysms. The use of physical training models based on phantoms presents a potential solution to this issue. PVA-H (polyvinyl alcohol hydrogel) is a material commonly employed to simulate human tissues due to its adjustable mechanical properties. The ability to modify the mechanical strength and elasticity of PVA-H renders it a suitable material for the development of vascular phantoms that replicate intracranial aneurysms. In this study, a phantom model of the internal carotid artery (ICA) with an intracranial aneurysm was successfully fabricated, featuring a maximum aneurysm width of 8.14 ± 0.07 mm and a wall thickness of 0.29 ± 0.05 mm. The outer diameter of the ICA vessel was measured at 4.43 ± 0.09 mm, with a wall thickness of 0.78 ± 0.22 mm. The compliance value obtained was 32,8 (mm/mmHg × 10-3 ), which closely approximates the compliance of human cerebral blood vessels. The optimal material composition for this phantom was determined to be 15%wt PVA-H combined with a mixture of 80% DMSO and 20% deionized water. Further modifications included the development of a brain tissue phantom composed of 2.2%wt silicone or 5%wt PVA-H (40% DMSO, 60% deionized water), which exhibited an elasticity modulus comparable to that of grey matter. Additionally, a Newtonian blood mimic was formulated, possessing a density of 1073.7 kg/m3 and a viscosity of 3.81 ± 0.34 mPa·s. The resulting phantom demonstrates significant potential as a training tool for the coiling procedure. However, this research remains constrained to the development of the internal carotid artery (ICA) phantom, brain tissue phantom, and artificial blood fluid without integrating the entire phantom and its modifiers.