BORON-DOPED DIAMOND MODIFIED WITH MXENE NANOSHEETS AND GOLD NANOPARTICLES AS A HIGH-PERFORMANCE NON-ENZYMATIC GLUCOSE SENSOR

• Main Author: Firly Sriramadhani, Neng
• Format: Final Project
• Language: Indonesia
• Subjects: Kimia
• Online Access: https://digilib.itb.ac.id/gdl/view/87520
• Institution: Institut Teknologi Bandung

Accurate and real-time blood glucose monitoring is crucial for diabetes management. Current enzymatic glucose sensors face challenges related to low stability and sensitivity. To address this, non-enzymatic glucose sensors have been developed, offering improved stability and environmental tolerance. This study explores the potential of boron-doped diamond (BDD)-based nanocomposites, MXene V2C/Ti3C2, and gold nanoparticles (AuNPs) as non-enzymatic glucose sensors. The successful synthesis of MXene was confirmed using X-ray Diffraction (XRD) and Scanning Electron Microscopy (SEM). XRD results showed characteristic diffraction peaks of MXene (V2C and Ti3C2) at angle 2? = 8°, confirming the interlayer spacing corresponding to exfoliated MXene nanosheets. SEM images revealed an increased interlayer spacing of MXene, forming a layered structure. The successful modification of BDD- V2C and BDD-V2C-AuNP electrodes was validated using SEM and X-ray Photoelectron Spectroscopy (XPS). SEM images demonstrated the homogeneous distribution of MXene nanosheets and MXene-AuNPs at a magnification of 5 µm on the BDD surface. XPS analysis confirmed the presence of key elements, including Ti, C, and Au, with a binding energy of Au 4f at 84.0 eV, indicating successful AuNP functionalization. Cyclic voltammetry results, measured at a scan rate of 50 mV/s with a potential range of 0 to 0.8 V vs Ag/AgCl, showed that the BDD-V2C-AuNP electrode exhibited the best electrochemical performance among the four tested electrodes (BDD- V2C, BDD-V2C-AuNPs, BDD-Ti3C2, and BDD-Ti3C2-AuNPs). This electrode demonstrated the highest sensitivity of 24.14 ?A ppm?1cm?2 the lowest limit of detection (LOD) of 0.15 ppm, the best repeatability/short-term stability with a relative standard deviation (RSD) of 0.73%, and the highest long-term stability with an I/I0 value of 0.93. With these exceptional performance characteristics, the BDD-V2C-AuNP nanocomposite exhibits great potential as an accurate, stable, and environmentally robust non-enzymatic glucose sensor for neutral and extreme pH conditions. This study opens new opportunities in developing glucose sensor technologies to support more effective diabetes management.