#TITLE_ALTERNATIVE#

• Main Author: Cholies , Noor
• Format: Dissertations
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/8830
• Institution: Institut Teknologi Bandung

Abstract: <br /> <br /> <br /> Research is still in progress in many countries to look for anticancer agents from plants or from synthetic compounds. <br /> <br /> <br /> In Indonesia Vernon:ia;cinerea herbs are frequently used in cancer treatment. The purpose of this research is to find out whether this medicinal plant contains any compound having anticancer activity. <br /> <br /> <br /> For this purpose, a cancerous tissue is needed. It has been succesfully developed by injecting benzo(a)pyrene (BP) in the neck of the Muang Thai strain mice. It appeared that the cancerous tissue caused by BP could be succesfully <br /> <br /> <br /> transplanted in other mice of similar strain. The existence of cancer in all of these investigations were proved by histophatological experiments. <br /> <br /> <br /> Further investigation revealed that the cancerous tissues were considerably different from the normal one viz., the 002 of cancerous cells were significantly lower <br /> <br /> <br /> than normal tissues as determined by the Warburg respirometer. Enzymic experiments showed that the specific activities of Slutamate oxaloacetate transaminase (GOT, glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDK) of cancerous tissues were distinctly lower than those of the normal one. On the other hand no differences in the specific activities of both alkaline and acid phosphatases were observed, <br />