#TITLE_ALTERNATIVE#

• Main Author: Sofiah (NIM 207 93 012), Siti
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/9279
• Institution: Institut Teknologi Bandung

Abstract : <br /> <br /> <br /> Nitrofurantoin tablet having dissolution not less than and closed to 25% in 60 minutes and maximum dissolution not less than 85% in 120 minutes has been formulated. The tablets were made by wet and dry granulations using hydroxypropyl methylcellulose 4,000 and 15,000 cps as matrix, and various concentrations of Amprotab and Primojel as internal and external disintegrants The dissolution test was performed according to USP XXII method that conform to dissolution requirement mentioned above. The result showed that the amount of nitrofurantoin dissolved in 60 minutes was 33.50% and in 120 minutes was 87.12% for tablet made by wet granulation using 10% of hydroxypropyl methylcellulose 4,000 cps as matrix, 5% of Primojel each as internal and external disintegrants and lactose as filler, meet the experimental requirement. The bioavailability test of tablet that meet the requirement, the tablet having the slowest dissolution (the amount of nitrofurantoin dissolved in 6o minutes was 14.91% and in 120 minutes was 24.20%) and commercial nitrofurantoin capsul has been studied in six healthy male volunteers according to a three-way crossover design . The tablet that meet the experimental requirement and the tablet having the slowest dissolution showed a correlation between dissolution and bioavailability, commercial nitrofurantoin capsul having high dissolution in 60 minutes did not show any correlation. <br />