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Quinine demethylation was carried out by refluxing quinine in the mixture of hydroiodic and glacial acetic acid for 12 hours at 127oC. The product was purified by precipitation, <br /> <br /> crystallization, and liquid-liquid extraction followed by preparative TLC. Two isolates were suc...
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| Institution: | Institut Teknologi Bandung |
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id-itb.:94112008-04-29T10:11:55Z#TITLE_ALTERNATIVE# SUSILAWATI (NIM 10703073), SUSI Indonesia Final Project INSTITUT TEKNOLOGI BANDUNG https://digilib.itb.ac.id/gdl/view/9411 Quinine demethylation was carried out by refluxing quinine in the mixture of hydroiodic and glacial acetic acid for 12 hours at 127oC. The product was purified by precipitation, <br /> <br /> crystallization, and liquid-liquid extraction followed by preparative TLC. Two isolates were successfully isolated and characterized by UV, fluorescence, and IR spectrometric techniques. Isolate A showed maximum absorbance at 371 nm, maximum emission fluorescence at 440 nm, and IR absorbance at 3428 and 1619 cm-1 which indicate the presence of C=C double bond and –OH phenolic groups. Isolate B showed maximum absorbance at 419 and 441 nm, maximum emission fluorescence at 465 nm, and IR absorbance at 3451 and 462 cm-1 which indicate the presence of C-I bond and –OH phenolic groups. These results showed that both isolates constitute the quinine derivatives which successfully demethylized, and in the case of isolate B the addition reaction was also occured. text |
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Quinine demethylation was carried out by refluxing quinine in the mixture of hydroiodic and glacial acetic acid for 12 hours at 127oC. The product was purified by precipitation, <br />
<br />
crystallization, and liquid-liquid extraction followed by preparative TLC. Two isolates were successfully isolated and characterized by UV, fluorescence, and IR spectrometric techniques. Isolate A showed maximum absorbance at 371 nm, maximum emission fluorescence at 440 nm, and IR absorbance at 3428 and 1619 cm-1 which indicate the presence of C=C double bond and –OH phenolic groups. Isolate B showed maximum absorbance at 419 and 441 nm, maximum emission fluorescence at 465 nm, and IR absorbance at 3451 and 462 cm-1 which indicate the presence of C-I bond and –OH phenolic groups. These results showed that both isolates constitute the quinine derivatives which successfully demethylized, and in the case of isolate B the addition reaction was also occured. |
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Final Project |
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SUSILAWATI (NIM 10703073), SUSI |
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SUSILAWATI (NIM 10703073), SUSI #TITLE_ALTERNATIVE# |
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SUSILAWATI (NIM 10703073), SUSI |
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SUSILAWATI (NIM 10703073), SUSI |
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https://digilib.itb.ac.id/gdl/view/9411 |
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