#TITLE_ALTERNATIVE#

• Main Author: INDRAWATI, TETI
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/9473
• Institution: Institut Teknologi Bandung

In vitro and in vivo evaluations of acetazolamide microcapsules had been investigated. Acetazolamide microcapsules were prepared by coacervation-phase separation method using melting and cooling dispersion techniques. Microcapsules were prepared using 1 part of acetazolamide to 2 Watts and 3 parts of cera alba with 0.50 , 0.75 and 1.00% surfactan combination - span 80 and tween 80 - having an HLB of 10. In vitro evaluation showed that microcapsules producted, had an average diameter betwen 395,74 to 677.17 um with oval shapes, active ingredient recoitvering factors betwen 0.91 to 0.98 and theoritical average of wall thickness betwen 21.17 to 30.79 um The amount dissoluted of acetazolamide from microcapsules after 6,5 hours were between 23.39 to 38.59% and its release followed the first order kinetics. Acetazolamide microcapsules, prepared using-1 part of.aaetazolamide to 2 part of cera alba with 1.00% surfactan combination (HLB 10), given to 3 rabbits produced a constant blood concentration of about 20 to 25 ug/ml, which occured 6 hours after an oral administration. On the other hand acetazolamide microcapsules prepared using 1 part of acetazolamide to 3 parts of acera alba with 0.50% surfactan combination (HLB -10), given to 3 rabbits produced a constant blood concentration of about 20-25 ug/mi, which occured 4 hours after the oral administration. The results of in vitro and in vivo evaluations showed that ecetazolamide microcapsules were supposed to be a sustained released dosage forms having a first order kinetics.