Interleukin-28B Polymorphisms and Response of Chronic Hepatitis C Patients from Indonesia to Pegylated Interferon/Ribavirin Treatment

• Main Authors: Juniastuti, Bogi P. Wibowo, I. D. N. Wibawa, Takako Utsumi, Syifa Mustika, Mochammad Amin, Rury M. Wahyuni, Hendra Kurniawan, Agus Hendrayana, Poernomo Boedi Setiawan, Laura N. Yamani, Soetjipto, Yoshihiko Yano, Hak Hotta, Yoshitake Hayashi, Maria Inge Lusida
• Format: Article PeerReviewed
• Language: English; English; English
• Published: American Society for Microbiology 2014
• Subjects: R Medicine (General); RC Internal medicine
• Online Access: http://repository.unair.ac.id/100207/1/Interleukin-2B.pdf; http://repository.unair.ac.id/100207/2/Interleukin.pdf; http://repository.unair.ac.id/100207/3/Interleukin-28B%20polymorphinms%20and%20response%20of%20chronic%20hepatitis%20C%20patients%20from%20indonesia%20to%20pegylated%20interferon%20_%20ribavirin%20treatment.pdf; http://repository.unair.ac.id/100207/; https://jcm.asm.org/content/52/6/2193.long
• Institution: Universitas Airlangga

This study demonstrated that Indonesian patients with chronic hepatitis C (mostly ethnic Java people) mostly were infected with hepatitis C virus (HCV) genotype 1; however, they carried mainly the major genotypes of interleukin 28B (IL-28B) single nucleotide polymorphisms (SNPs) (rs12979860 CC, rs11881222 TT, rs8103142 AA, and rs8099917 TT), and they mostly achieved sustained virological responses to pegylated interferon/ribavirin treatment.