Ultradeep Sequencing for Detection of Quasispecies Variants in the Major Hydrophilic Region of Hepatitis B Virus in Indonesian Patients

• Main Authors: Laura Navika Yamani, Yoshihiko Yano, Takako Utsumi, Juniastuti, Hadi Wandono, Doddy Widjanarko, Ari Triantanoe, Widya Wasityastuti, Yujiao Liang, Rina Okada, Toshihito Tanahashi, Yoshiki Murakami, Takeshi Azuma, Soetjipto, Maria Inge Lusida, Yoshitake Hayashi
• Format: Article PeerReviewed
• Language: English; English; English
• Published: American Society for Microbiology 2016
• Subjects: R Medicine (General); RC Internal medicine
• Online Access: http://repository.unair.ac.id/100229/1/Ultradeep%20Sequencing.pdf; http://repository.unair.ac.id/100229/2/Ultradeep.pdf; http://repository.unair.ac.id/100229/3/Ultradeep%20sequencing%20for%20detection%20of%20quasispecies%20variants%20in%20the%20major%20hydrophilic%20region%20of%20hepatitis%20B%20Virus%20In%20Indonesia%20patients.pdf; http://repository.unair.ac.id/100229/; https://jcm.asm.org/content/53/10/3165.long
• Institution: Universitas Airlangga

Quasispecies of hepatitis B virus (HBV) with variations in the major hydrophilic region (MHR) of the HBV surface antigen (HBsAg) can evolve during infection, allowing HBV to evade neutralizing antibodies. These escape variants may contribute to chronic infections. In this study, we looked for MHR va...