Concanavalin A Enhanced Proliferation and Osteogenic Differentiation of Dental Pulp Stem Cells
Objective Dental pulp stem cells (DPSCs) can be used as a component in the formation of regenerative dentine during direct pulp capping therapy. Concanavalin A (ConA) is a type of lectin with a molecular weight of 26 kDa derived from the Canavalia ensiformis plant. Lectins possess strong proliferati...
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id-langga.1018372023-04-16T03:09:15Z https://repository.unair.ac.id/101837/ Concanavalin A Enhanced Proliferation and Osteogenic Differentiation of Dental Pulp Stem Cells Ketut Suardita, - Ira Arundina, - Udijanto Tedjosasongko, - Anita Yuliati, - Harry Huiz Peeters, - I Komang Evan Wijaksana, - Meircurius Dwi Condro Surboyo, - R Medicine RK Dentistry Objective Dental pulp stem cells (DPSCs) can be used as a component in the formation of regenerative dentine during direct pulp capping therapy. Concanavalin A (ConA) is a type of lectin with a molecular weight of 26 kDa derived from the Canavalia ensiformis plant. Lectins possess strong proliferation and differentiation abilities in various animal cells including lymphocytes, osteoblasts, and chondrocytes. The aim of study was to determine the effect of ConA on the proliferation and osteogenic differentiation of DPSCs in vitro. Materials and Methods In this in vitro study, DPSCs were isolated from third molars before ConA induction was performed at concentrations of 5 and 10 μg/mL. The proliferation assay was determined by 3-(4,5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Osteogenic differentiation was determined by means of mineralization. Statistical Analysis Data were analyzed using analysis of variance and a Student’s t-test. The p-value was set at 0.05. Results The addition of 5 and 10 µg/mL of ConA to DPSCs can significantly increase the proliferation and osteogenic differentiation of DPSCs (p ≤0.05). Conclusion ConA can increase the proliferation and osteogenic differentiation of DPSCs. Dental Investigation Society 2020 Article PeerReviewed text en cc_by_nc_nd_4 https://repository.unair.ac.id/101837/1/Concanavalin%20A%20Enhanced%20Proliferation.pdf text en https://repository.unair.ac.id/101837/2/Concanavalin%20A%20Enhanced%20Proliferation%20and%20Osteogenic%20Differentiation%20of%20Dental%20Pulp%20Stem%20Cells%202.pdf text id https://repository.unair.ac.id/101837/3/12concanavalin.pdf text id https://repository.unair.ac.id/101837/6/6.%20Udijanto%20Internasional%20%28%20Concanavalin...%29.pdf text en https://repository.unair.ac.id/101837/7/Concanavalin.pdf text en https://repository.unair.ac.id/101837/8/14T.pdf text en https://repository.unair.ac.id/101837/10/20230413164828.pdf Ketut Suardita, - and Ira Arundina, - and Udijanto Tedjosasongko, - and Anita Yuliati, - and Harry Huiz Peeters, - and I Komang Evan Wijaksana, - and Meircurius Dwi Condro Surboyo, - (2020) Concanavalin A Enhanced Proliferation and Osteogenic Differentiation of Dental Pulp Stem Cells. European Journal of Dentistry, 14 (1). pp. 123-127. ISSN 1305-7456 https://www.thieme-connect.de/products/ejournals/html/10.1055/s-0040-1702900 https://doi.org/ 10.1055/s-0040-1702900 |
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R Medicine RK Dentistry Ketut Suardita, - Ira Arundina, - Udijanto Tedjosasongko, - Anita Yuliati, - Harry Huiz Peeters, - I Komang Evan Wijaksana, - Meircurius Dwi Condro Surboyo, - Concanavalin A Enhanced Proliferation and Osteogenic Differentiation of Dental Pulp Stem Cells |
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Objective Dental pulp stem cells (DPSCs) can be used as a component in the formation of regenerative dentine during direct pulp capping therapy. Concanavalin A (ConA) is a type of lectin with a molecular weight of 26 kDa derived from the Canavalia ensiformis plant. Lectins possess strong proliferation and differentiation abilities in various animal cells including lymphocytes, osteoblasts, and chondrocytes. The aim of study was to determine the effect of ConA on the proliferation and osteogenic differentiation of DPSCs in vitro.
Materials and Methods In this in vitro study, DPSCs were isolated from third molars before ConA induction was performed at concentrations of 5 and 10 μg/mL. The proliferation assay was determined by 3-(4,5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Osteogenic differentiation was determined by means of mineralization.
Statistical Analysis Data were analyzed using analysis of variance and a Student’s t-test. The p-value was set at 0.05.
Results The addition of 5 and 10 µg/mL of ConA to DPSCs can significantly increase the proliferation and osteogenic differentiation of DPSCs (p ≤0.05).
Conclusion ConA can increase the proliferation and osteogenic differentiation of DPSCs. |
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Article PeerReviewed |
author |
Ketut Suardita, - Ira Arundina, - Udijanto Tedjosasongko, - Anita Yuliati, - Harry Huiz Peeters, - I Komang Evan Wijaksana, - Meircurius Dwi Condro Surboyo, - |
author_facet |
Ketut Suardita, - Ira Arundina, - Udijanto Tedjosasongko, - Anita Yuliati, - Harry Huiz Peeters, - I Komang Evan Wijaksana, - Meircurius Dwi Condro Surboyo, - |
author_sort |
Ketut Suardita, - |
title |
Concanavalin A Enhanced Proliferation and Osteogenic Differentiation of Dental Pulp Stem Cells |
title_short |
Concanavalin A Enhanced Proliferation and Osteogenic Differentiation of Dental Pulp Stem Cells |
title_full |
Concanavalin A Enhanced Proliferation and Osteogenic Differentiation of Dental Pulp Stem Cells |
title_fullStr |
Concanavalin A Enhanced Proliferation and Osteogenic Differentiation of Dental Pulp Stem Cells |
title_full_unstemmed |
Concanavalin A Enhanced Proliferation and Osteogenic Differentiation of Dental Pulp Stem Cells |
title_sort |
concanavalin a enhanced proliferation and osteogenic differentiation of dental pulp stem cells |
publisher |
Dental Investigation Society |
publishDate |
2020 |
url |
https://repository.unair.ac.id/101837/1/Concanavalin%20A%20Enhanced%20Proliferation.pdf https://repository.unair.ac.id/101837/2/Concanavalin%20A%20Enhanced%20Proliferation%20and%20Osteogenic%20Differentiation%20of%20Dental%20Pulp%20Stem%20Cells%202.pdf https://repository.unair.ac.id/101837/3/12concanavalin.pdf https://repository.unair.ac.id/101837/6/6.%20Udijanto%20Internasional%20%28%20Concanavalin...%29.pdf https://repository.unair.ac.id/101837/7/Concanavalin.pdf https://repository.unair.ac.id/101837/8/14T.pdf https://repository.unair.ac.id/101837/10/20230413164828.pdf https://repository.unair.ac.id/101837/ https://www.thieme-connect.de/products/ejournals/html/10.1055/s-0040-1702900 https://doi.org/ 10.1055/s-0040-1702900 |
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