Flavonoids with antiplasmodial and cytotoxic activities of Macaranga triloba
A new flavanone derivative, malaysianone A (1), four prenylated flavanones, 6-prenyl-3′-methoxyeriodictyol (2), nymphaeol B (3), nymphaeol C (4) and 6-farnesyl-3′,4′,5,7-tetrahydroxyflavanone (5), and two coumarins, 5,7-dihydroxycoumarin (6) and scopoletin (7), were isolated from the dichloromethane...
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| Main Authors: | , , , |
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| Format: | Article PeerReviewed |
| Language: | English English English |
| Published: |
Elsevier B.V.
2012
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/102674/1/C-14-fitoterapia.pdf http://repository.unair.ac.id/102674/2/scan%20validasi%20C-14.pdf http://repository.unair.ac.id/102674/5/Result%20Flavonoids%20with%20antiplasmodial%20and%20cytotoxic%20activities%20of%20Macaranga%20triloba.pdf http://repository.unair.ac.id/102674/ https://www.sciencedirect.com/science/article/abs/pii/S0367326X1200127X https://doi.org/10.1016/j.fitote.2012.04.020 |
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| Institution: | Universitas Airlangga |
| Language: | English English English |
| Summary: | A new flavanone derivative, malaysianone A (1), four prenylated flavanones, 6-prenyl-3′-methoxyeriodictyol (2), nymphaeol B (3), nymphaeol C (4) and 6-farnesyl-3′,4′,5,7-tetrahydroxyflavanone (5), and two coumarins, 5,7-dihydroxycoumarin (6) and scopoletin (7), were isolated from the dichloromethane extract of the inflorescences of Macaranga triloba. The structures of these compounds were elucidated based on spectroscopic methods including nuclear magnetic resonance (NMR-1D and 2D), UV, IR and mass spectrometry. The cytotoxic activity of the compounds was tested against several cell lines, with 5 inhibiting very strongly the growth of HeLa and HL-60 cells (IC50: 1.3 μg/ml and 3.3 μg/ml, respectively). Compound 5 also showed strong antiplasmodial activity (IC50: 0.06 μM). |
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