Adjuvant Therapy of Syzygium cumini Leaf and Fruit Extract Nanoparticles in Mice (Mus musculus) Infected by Plasmodium berghei

• Main Authors: Lilik Maslachah, -, Rahmi Sugihartuti, -, Retno Sri Wahjuni, -, Lita Rakhma Yustinasari, -
• Format: Article PeerReviewed
• Language: English; English; English; English
• Published: Indian Veterinary Journal 2020
• Subjects: SF405.5-407 Laboratory animals; SF811-909 Veterinary medicine of special organs, regions, and systems
• Online Access: https://repository.unair.ac.id/104323/5/Bukti%20C01_Adjuvan%20Therapy%20of%20Syzygium%20cumini%20leaf%20and%20fruit%20Extract%20nanoparticles%20in%20mice%28mus%20musculus%29%20infected%20by%20plasmodium%20berghei.pdf; https://repository.unair.ac.id/104323/2/Peer%20review%20C01_Adjuvant%20Therapy%20of%20Syzygium%20cumini%20Leaf%20and%20Fruit%20Extract%20Nanoparticles%20in%20Mice%20%28Mus%20muculus%29%20Infected%20by%20Plasmodium%20berghei.%28Penulis%20Pertama%29.pdf; https://repository.unair.ac.id/104323/3/C%2001.%20Adjuvant%20Therapy%20of%20Syzygium%20cumini%20Leaf%20and%20....pdf; https://repository.unair.ac.id/104323/8/%28bukti%20korespondensi%29%20Adjuvant%20Therapy%20of%20Syzygium%20cumini%20Leaf%20and%20Fruit%20Extract%20Nanoparticles%20in%20Mice%20%28Mus%20musculus%29%20Infected%20by%20Plasmodium%20berghei.pdf; https://repository.unair.ac.id/104323/
• Institution: Universitas Airlangga

The aim was determine the efficacy of Syzygium cumini leaf and fruit extracts nanoparticles to mice infected with Plasmodium berghei at 1x105 of Plasmodium berghei. Treatment was given 24 hours post infection for 4 days. Observed from the 5th day to 12th day post infection. The results of per cent parasitemia, growth inhibition, Parasite Clearance Time, and Recrudescence Time of parasites. Syzygium cumini fruit nanoparticles with chloroquine were better than Syzygium cumini leaf nanoparticles with chloroquine, whereas the Survival time, Hb content, splenic index and liver index were same. Efficacy of Syzygium cumini leaf and fruit extracts nanoparticles increased when used as an adjuvant therapy with chloroquin in mice infected by Plasmodium berghei Keywords : Nanoparticle, Syzygium cumini, Plasmodium berghei, Therapy